ID A0A0G0N871_9BACT Unreviewed; 716 AA.
AC A0A0G0N871;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Polymerase I protein {ECO:0000313|EMBL:KKR12369.1};
GN ORFNames=UT41_C0002G0143 {ECO:0000313|EMBL:KKR12369.1};
OS Candidatus Wolfebacteria bacterium GW2011_GWC2_39_22.
OC Bacteria; Candidatus Wolfebacteria.
OX NCBI_TaxID=1619013 {ECO:0000313|EMBL:KKR12369.1, ECO:0000313|Proteomes:UP000034665};
RN [1] {ECO:0000313|EMBL:KKR12369.1, ECO:0000313|Proteomes:UP000034665}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKR12369.1}.
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DR EMBL; LBWR01000002; KKR12369.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0N871; -.
DR STRING; 1619013.UT41_C0002G0143; -.
DR PATRIC; fig|1619013.3.peg.796; -.
DR Proteomes; UP000034665; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd09898; H3TH_53EXO; 1.
DR CDD; cd09859; PIN_53EXO; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR InterPro; IPR002421; 5-3_exonuclease.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR020045; DNA_polI_H3TH.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF01367; 5_3_exonuc; 1.
DR Pfam; PF02739; 5_3_exonuc_N; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00475; 53EXOc; 1.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..268
FT /note="5'-3' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00475"
FT DOMAIN 473..680
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 716 AA; 80556 MW; 79BA6199B45ACF32 CRC64;
MKKLLLIDAN ALIHRAFHAI PNLTTPDGRP SGALYGLTNV LIKIFKEEHP EYAVAFFDRP
EPTFRKEMYA EYKAHRPKAP DELISQIIEA HHLFDVFGVK TYEIPGFEGD DLIGTAAEQF
KGEKDVQVVV LTGDLDALQL VEGNKVVVET LKQGISETIT YDETAVVARY GISPSQLADY
KGLVGDASDN ISGVRGVGPK TASGIIQEFG SLENFFATIK VSDDAGKKML SYKKLIEHEE
IALLSKTLAT IRRDAPIGIQ SISEIAYTAF PTETVIPYLK DMGFTSILKR LVPAENEIRV
ARQKAQENQG QLFSLTSQPT LSQQLLDDVE LPLVSILEEM NQYGIMIDRT RLAEKEVILD
RDIDALVKEL YREAGHVFNP NSPKQLLEIL KTTYKLKIKS TNIDKIEQFR STVPFIDLIL
KYRELFKLKS TYLEPIKRMS ELDTRIHPTF VQLKAATGRI TCEHPNLQNI PPSIREIFVA
SSGYKLVSLD YSQIELRILA SLTEDPEMLR AFKSNADIHQ ITASKIYNVS LEEVTPVMRK
VAKTLNFGVI YGMGARALAQ QSGLTPKEAK LFIDEYFSDF STIKQWQETI LATVRTQGFV
ENINGRMRPL PEIMSFNKML QSEAERMAIN FPIQSVAADI IKSAMVKVKE HFSSKGIWGT
DVKMLLTIHD ELVFEIKDTD RLLATVTEIK DIMESIYTLN VPLTVNLEIG DNWGEL
//
