ID A0A0G0Q031_9BACT Unreviewed; 85 AA.
AC A0A0G0Q031;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Fluoride-specific ion channel {ECO:0000256|RuleBase:RU004340};
GN ORFNames=UT63_C0094G0002 {ECO:0000313|EMBL:KKR30721.1};
OS Candidatus Gottesmanbacteria bacterium GW2011_GWC2_39_8.
OC Bacteria; Candidatus Gottesmanbacteria.
OX NCBI_TaxID=1618450 {ECO:0000313|EMBL:KKR30721.1, ECO:0000313|Proteomes:UP000034539};
RN [1] {ECO:0000313|EMBL:KKR30721.1, ECO:0000313|Proteomes:UP000034539}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- FUNCTION: Important for reducing fluoride concentration in the cell,
CC thus reducing its toxicity. {ECO:0000256|RuleBase:RU004340}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=fluoride(in) = fluoride(out); Xref=Rhea:RHEA:76159,
CC ChEBI:CHEBI:17051; Evidence={ECO:0000256|ARBA:ARBA00035585};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:76160;
CC Evidence={ECO:0000256|ARBA:ARBA00035585};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fluoride channel Fluc/FEX (TC 1.A.43)
CC family. {ECO:0000256|ARBA:ARBA00035120, ECO:0000256|RuleBase:RU004340}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU004340}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKR30721.1}.
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DR EMBL; LBXN01000094; KKR30721.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0Q031; -.
DR Proteomes; UP000034539; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR InterPro; IPR003691; FluC.
DR Pfam; PF02537; CRCB; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004340};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU004340};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU004340}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT TRANSMEM 32..54
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004340"
SQ SEQUENCE 85 AA; 9104 MW; 7DBBA4B19858E88E CRC64;
MRFLFIGVGG AIGSLFRYIV SGLTYKFFDG VFPWGTLAVN LIGSLAAGFL WGLFEAVIIQ
PNIRTFIFVG TALGCPRTGS SPIPT
//
