ID A0A0G0RMQ4_9BACT Unreviewed; 329 AA.
AC A0A0G0RMQ4;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=histidine--tRNA ligase {ECO:0000256|ARBA:ARBA00012815};
DE EC=6.1.1.21 {ECO:0000256|ARBA:ARBA00012815};
DE Flags: Fragment;
GN ORFNames=UT43_C0013G0001 {ECO:0000313|EMBL:KKR14897.1};
OS Parcubacteria group bacterium GW2011_GWC1_39_29.
OC Bacteria.
OX NCBI_TaxID=1618900 {ECO:0000313|EMBL:KKR14897.1, ECO:0000313|Proteomes:UP000034254};
RN [1] {ECO:0000313|EMBL:KKR14897.1, ECO:0000313|Proteomes:UP000034254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-
CC histidyl-tRNA(His); Xref=Rhea:RHEA:17313, Rhea:RHEA-COMP:9665,
CC Rhea:RHEA-COMP:9689, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57595, ChEBI:CHEBI:78442,
CC ChEBI:CHEBI:78527, ChEBI:CHEBI:456215; EC=6.1.1.21;
CC Evidence={ECO:0000256|ARBA:ARBA00001137};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00008226}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKR14897.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LBWT01000013; KKR14897.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0RMQ4; -.
DR Proteomes; UP000034254; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004821; F:histidine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0006427; P:histidyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00773; HisRS-like_core; 1.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR015807; His-tRNA-ligase.
DR InterPro; IPR041715; HisRS-like_core.
DR InterPro; IPR004516; HisRS/HisZ.
DR NCBIfam; TIGR00442; hisS; 1.
DR PANTHER; PTHR11476:SF7; HISTIDINE--TRNA LIGASE; 1.
DR PANTHER; PTHR11476; HISTIDYL-TRNA SYNTHETASE; 1.
DR Pfam; PF13393; tRNA-synt_His; 1.
DR PIRSF; PIRSF001549; His-tRNA_synth; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:KKR14897.1}.
FT DOMAIN 1..133
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
FT NON_TER 329
FT /evidence="ECO:0000313|EMBL:KKR14897.1"
SQ SEQUENCE 329 AA; 36386 MW; 2628CB58E5578879 CRC64;
MADYIEPKLA SGFKDYLPED MIPRQEMFDR IRAVFENFGF VPLDTPGLEK DEIITGGDPD
FKMNVWHASI KDDSEKMALR FDLTVPLARV VAGNPDIKKP FKRYQIGKVW RGERPQAGRY
REFVQFDADI VGSTSVLADA EIIAIMNATM IALEIPNFLI RINNRKILNG LTEYAGFSPD
KNSAVLRAID KLDKQGWDKV STELCDAKIG LTSEQAEAIK KFVDLRAHTP IETLDAVEAL
MIKSPTAMNG ISELRELVDA IKAMGVPDEK WKIDLSIARG LGYYTGPVFE TVLTDILEIG
SVFSGGRYDG LVSKFSAQSV PATGASVGV
//
