ID A0A0G0RPL1_9BACT Unreviewed; 972 AA.
AC A0A0G0RPL1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=UT89_C0005G0013 {ECO:0000313|EMBL:KKR51856.1};
OS Parcubacteria group bacterium GW2011_GWE1_40_20.
OC Bacteria.
OX NCBI_TaxID=1618946 {ECO:0000313|EMBL:KKR51856.1, ECO:0000313|Proteomes:UP000034131};
RN [1] {ECO:0000313|EMBL:KKR51856.1, ECO:0000313|Proteomes:UP000034131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKR51856.1}.
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DR EMBL; LBYN01000005; KKR51856.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0RPL1; -.
DR PATRIC; fig|1618946.3.peg.798; -.
DR Proteomes; UP000034131; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 8..328
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 329..590
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 29..36
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 972 AA; 110296 MW; AF46AEDFF43ED03C CRC64;
MSFEERYAKL NKEQKMAVDT IDGPVLVVAG PGTGKTTILT LRIAEILRKT DTPAHGILAI
TYTDAGVRAM REKLREIIGN RAHDVYIHTF HSFASAMMSE YPDHFLRIGD FKQMTDVDQE
SFIRDIISES IFAPLRPIGR PDVYISSIIK TISDAKKDAL TPEDVRDFVK KEIKNIKNDE
SNISTRGATK GKLKADALNK LEKLDKTLLF ADVYKKYEEK KKEAKLKDYD DLIIELLVTM
RTDELLLRLI QERFLYLLVD EHQDTNDSQN LIISLIAEFF ETPNIFIVGD EKQAIYRFQG
ASVENFLKLQ KHWPSMKVIN LDTNYRSHQG ILDASFAMIE NNYDEGEYVD LRKKLKSGNK
EKAHPLDILV GENTPAIEHY LVDRLRDISR KEPEATVAII TRRNRELERV LRLLESQNIL
VSSERSLDIF HHPLGIAFFD LIEYIADPSR FDFLAKTLII GMWGVSFGKS LEIIHLLKSG
QVENLHSFIP AISRIREKML HDGAVSGIIH LAEESGFVGL VAKDPSFVHV WKGIVTLAES
LARDGDIISP LELMNMMLKY RQSAESKTVK VSVGAPDFPI KAMTAHGSKG LEFDYVFIPY
ANEESWVGRS HGSSFVLPGR GLNDNDIRDT RRLFYVAITR ARKHAVILYS TEESDGKMLT
PLRFVGELHK DCTTETCLER KDVHLSDLKK EKITENENDA LMVSEAKKVL LQNGLSVTAL
NHFLECPSKF LYESILKMPQ APSLSSEKGS AMHEAMRRIW TKRENTPKQT EETIISTTTE
YINKSLLSQE DKTRLKAELS EDAHFVAEAL VSHFSSNGSV STERWFEAPL DIKYDAKKII
INIHGKLDVV VDDGNAVSVF DYKTRQGMSV AAIKGETQNS EGNYFRQLVF YKMLLNNNSF
YQSKNINTSL VFISPDDKGR CPVVTLPVES DDISRVQAEI KSLVDSVWSG EITTKYCSDP
NCQYCGYRKL LK
//
