ID A0A0G0SF43_9BACT Unreviewed; 843 AA.
AC A0A0G0SF43;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=UT64_C0010G0009 {ECO:0000313|EMBL:KKR33335.1};
OS Candidatus Falkowbacteria bacterium GW2011_GWF2_39_8.
OC Bacteria; Candidatus Falkowbacteria.
OX NCBI_TaxID=1618642 {ECO:0000313|EMBL:KKR33335.1, ECO:0000313|Proteomes:UP000034137};
RN [1] {ECO:0000313|EMBL:KKR33335.1, ECO:0000313|Proteomes:UP000034137}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKR33335.1}.
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DR EMBL; LBXO01000010; KKR33335.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0SF43; -.
DR PATRIC; fig|1618642.3.peg.276; -.
DR Proteomes; UP000034137; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 7..342
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 374..656
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 28..35
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 843 AA; 97423 MW; 51EF24BF80EA2785 CRC64;
MPDNLMENLN SEQLKAVLHK DGPLLIVAGA GTGKTHAITQ KIGYMIEQGW AEPEEILALT
FTEKAAAEME ERVDRLLPMG YVDLWISTFH GFAEKILKAH GLDIGLPTQF KLINEFEQWR
LIQKNLDLFD LNYYKPAGNP TKFIEALIRH FSRLKDENIT PDDYLTYTSK LHSDLEKSSI
DKLKVKSKKL KVGHELTALE KLKLQLKVEN VTDDMLGQEV LRLAEVAKAY QIYQQLLLNE
GMMDFGDLIN YCLKLFKERP LLLAKHQEQF KYIVVDEFQD TNWSQYELVK LLAAKRRNLI
VVGDDDQSIY RFRGASMSNI LQFKNDYPDA EQVVLTENYR SKQNILDLSY EFIKLNNPNR
LEWQLSGAKI MQAEKKASVK TKAKTKEIVT LNKQLKSNQN DQGTIELIAA DTFEDEVRLV
IDKISEIKNS DKDLSWGDFS ILVRANDTAG EFCSELDKRN ISFQFLASRG LYVKPIIMDV
VAYLKLLDDY HESRAMYRVL NLPFLKFTYE ELVNFNYVSN KKACSLFETL RRADHEQYAE
ETRKKIFRIL TLISNHSKMA REKRVSEVVI AFMNESGYLK HIMGLPGREQ QENLSYLNQF
MKRLADFEQA TAEKTVKLFL EELDMEIMAG EEGALSPDLE IGPDTVKIMT VHASKGLEFK
YVFVVSMVDK RFPAIGRKDA IEIPNSLVKE VLPEGDSHLE EERRLFYVAM TRAKTGLFFS
WAKDYGGARG KKPSLFLVEL GLVDKQVVKG TVKKELDEEN FVSAKKEAKE QKEIFNLPKH
FSYSQLAAFQ NCPYQYRFAH ILKIPIRGKG VFSFGKTMHS TLQKTFELLR ERRESHKLPW
MRY
//
