ID A0A0G0UI80_9BACT Unreviewed; 491 AA.
AC A0A0G0UI80;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00020675, ECO:0000256|RuleBase:RU000644};
GN ORFNames=UU37_C0002G0043 {ECO:0000313|EMBL:KKR88528.1};
OS Candidatus Gottesmanbacteria bacterium GW2011_GWA2_41_12.
OC Bacteria; Candidatus Gottesmanbacteria.
OX NCBI_TaxID=1618440 {ECO:0000313|EMBL:KKR88528.1, ECO:0000313|Proteomes:UP000033908};
RN [1] {ECO:0000313|EMBL:KKR88528.1, ECO:0000313|Proteomes:UP000033908}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- FUNCTION: One of the essential components for the initiation of protein
CC synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC and promotes its binding to the 30S ribosomal subunits. Also involved
CC in the hydrolysis of GTP during the formation of the 70S ribosomal
CC complex. {ECO:0000256|RuleBase:RU000644}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733, ECO:0000256|RuleBase:RU000644}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKR88528.1}.
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DR EMBL; LCAJ01000002; KKR88528.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0UI80; -.
DR PATRIC; fig|1618440.3.peg.95; -.
DR Proteomes; UP000033908; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR000178; TF_IF2_bacterial-like.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00487; IF-2; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF5; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|RuleBase:RU000644};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU000644}.
FT DOMAIN 14..187
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 491 AA; 53201 MW; 0907916BB67CBA57 CRC64;
MSKKTAKIEP KINLRPPVVV VLGHVDHGKT TLLDTIRKTN VTEKEFGGIT QHIGAYQTIL
ETKEGKKKIT FIDTPGHAAF AKMRSRGAGV ADIAVLVVSA SDGVMPQTIE SIEHIRNASI
PFVVALNKID LPEANPEKIK GELVKQDVLL EGYGGDVPIV PLSAKKGTGI KDLLEIISLF
WEMKEHKEDT KQFTGTIIES NLDKNKGPVA TIIIRTGKLE IGDVLETEEV SGKIKAMLSD
QRISVKEALP GDPVEILGFS SVPKIGSRVW KKGEMVIVQE EKKEIEPLPP TEIEVAPTSA
VVEKRLKVII KADAYGSLEA ILGTVKQNDL EILLSAVGNI TESDILLAKT AGAFVIGFNM
KPSTQVTKLA ESEKVLIKTY NIIYEMLDEL EDVVKALREG GIDKILGEAQ IMARFDMKDG
VIAGVKIVSG KISRGDQIKV LRGKVEVGRA KIKSLRHAKD NISHAEPGTE AGLILSNKLD
FSVGDSIISI G
//
