ID A0A0G0UUZ3_9BACT Unreviewed; 906 AA.
AC A0A0G0UUZ3;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=UU43_C0008G0002 {ECO:0000313|EMBL:KKR91351.1};
OS Candidatus Falkowbacteria bacterium GW2011_GWA2_41_14.
OC Bacteria; Candidatus Falkowbacteria.
OX NCBI_TaxID=1618635 {ECO:0000313|EMBL:KKR91351.1, ECO:0000313|Proteomes:UP000034190};
RN [1] {ECO:0000313|EMBL:KKR91351.1, ECO:0000313|Proteomes:UP000034190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKR91351.1}.
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DR EMBL; LCAP01000008; KKR91351.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0UUZ3; -.
DR PATRIC; fig|1618635.3.peg.417; -.
DR Proteomes; UP000034190; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 3.90.220.10; Adenine-n6-DNA-methyltransferase Taqi, Chain A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR023135; N6_DNA_MeTrfase_TaqI_C.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR025931; TaqI_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF12950; TaqI_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF116734; DNA methylase specificity domain; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 315..641
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 716..833
FT /note="TaqI-like C-terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF12950"
SQ SEQUENCE 906 AA; 104732 MW; 2EF250F04BD95E7A CRC64;
MNNEQAKEKI KELIDKYHSV AASGKIKTYS EEETKLGFIQ PLFEALGWNV FDKNEVTAEE
QISGDRVDYG FYLNGRIKFY LEAKPLKADL YREEYAKQSI RYSWNKGVTW AVLTDFEGMI
VFNALSPEKS LAGKKYLSFT YEEYLTRFDE LWRLSKEAFG EDLLDKEAEK VGKKLQKISV
TETLAKDLNE CREILTRAFL QWNGKVDPHL IDEGVQKLLN RLIFIRSAED RKIEPLTLMP
LIHEYRGSGK AGQISPYQAM VQKFRELDKI YNSNMFDEHP FEKWEEFGGA TEKVVDILYG
KKNYFEYDFS VIPADVLGNV YESYLGHQLK KSKKQEESGK NLKKRKEQGI YYTPKYIVDY
IVTNALGPVL DKCKSINDLQ KIKILDPACG SGSFLVAAMN FLIKKYEEFG AKPDGYLKIQ
ILQQNIYGVD LDQQAVELAR LNLLLNTFDS QTKLPNLGGN IKNGNSLISG TDEELEKYFG
KNYRDKNPFN WQEEFSDVFK QGGFDCIIGN PPYINAKNGN FSDDEKVFYN IFFRTAEYQL
DTYILFTEQA VNLLKMSGSL GFIIPNSWLA NILLPKIRKF LLNETRVRKL VNIQQPTFKE
ASVDTMILVC NKENNIKSNN VEIASISDNR YQIIADTKQQ IFLNNTNCII NVSANNVSRK
IINHIEKQSK KIGDIIDIST GIKEYQVGKG KPPQTMDDKI NSNFNANFKK DKTYIPELRG
KNIFRYDFNW PESYVSYGNW LAEPRKEKYF EGQRILLRKI PAPNNLVAAL ISDRYIIDQS
LYIGKIKTKD FNPEFILGVL NSKLLGWYFR CKNNEFDDLF PQIKIGQFKD LPVVIKDKNN
QKILTDLVAK MLVLNNEIKK TTENSDQWQK IKAEIARTDK KIDEEVYGLY GLNKEEIEIV
ENSNKK
//
