ID   A0A0G0VI81_9BACT        Unreviewed;       533 AA.
AC   A0A0G0VI81;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=Sodium/hydrogen exchanger {ECO:0000313|EMBL:KKS00564.1};
GN   ORFNames=UU51_C0005G0009 {ECO:0000313|EMBL:KKS00564.1};
OS   Microgenomates group bacterium GW2011_GWC1_41_20.
OC   Bacteria.
OX   NCBI_TaxID=1618518 {ECO:0000313|EMBL:KKS00564.1, ECO:0000313|Proteomes:UP000033948};
RN   [1] {ECO:0000313|EMBL:KKS00564.1, ECO:0000313|Proteomes:UP000033948}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA   Wilkins M.J., Williams K.H., Banfield J.F.;
RT   "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT   radiation of phyla.";
RL   Nature 0:0-0(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC       transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKS00564.1}.
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DR   EMBL; LCAX01000005; KKS00564.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G0VI81; -.
DR   Proteomes; UP000033948; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR003148; RCK_N.
DR   PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR   PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02254; TrkA_N; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS51201; RCK_N; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        22..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        53..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        81..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        114..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        143..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        184..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        237..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        262..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        296..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        325..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          381..503
FT                   /note="RCK N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51201"
SQ   SEQUENCE   533 AA;  57075 MW;  D0BF5CF86C63EAB7 CRC64;
     MVGYIIAGII VGAILPSNFR QVSSLADVGI ILLLFSIGLE LSFDRLSRYL KIAVLGSLIQ
     IVLTVFFSYL ILSLFHLSTV AALVLSLGFS VSSTAVIVKI LGDKGELDTI HGGIIFGWLL
     VQDLAVVPMM VVLPFLAGES GSAAGGILLA LGKGALVILG VVFLGKKLVP LIIHRLAAIN
     SREILLLASI ALALGTAAVT SYFGISPALG AFLAGVVISG SQEDHAIFAE TRPLRDIFVA
     LFFVTLGFMV TPSVVISNIG LILALTAIVL LLKIVIVFII SFVFGYRGKT AIANSFALAQ
     VGEFAFVIFS GALALNLLTF IETSIGISVT LLTLVVSPIL YNLILPFWRK MKILTNNRPG
     LAKLFSAGEK HSIEAEGFRD HIIICGYGRV GKWIGKALQS FGVPFVVVEY NQTIVQELSV
     GGIPVLYGDP TEPEVLEAVG VRYSKAVILA IPDRVAQETL IAYVQTVAPA TKIISRAHQD
     SDWEKLKDLR VDKVVQPEFE AALAIVKSVF SSMGKSKEEI SAVTKSLRLS RNR
//