ID A0A0G0VXW7_9BACT Unreviewed; 747 AA.
AC A0A0G0VXW7;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=UU58_C0005G0011 {ECO:0000313|EMBL:KKS04562.1};
OS Candidatus Nomurabacteria bacterium GW2011_GWA2_41_25.
OC Bacteria; Candidatus Nomurabacteria.
OX NCBI_TaxID=1618736 {ECO:0000313|EMBL:KKS04562.1, ECO:0000313|Proteomes:UP000034236};
RN [1] {ECO:0000313|EMBL:KKS04562.1, ECO:0000313|Proteomes:UP000034236}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKS04562.1}.
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DR EMBL; LCBE01000005; KKS04562.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0VXW7; -.
DR PATRIC; fig|1618736.3.peg.245; -.
DR Proteomes; UP000034236; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 9..324
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 325..654
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 88..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 30..37
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 747 AA; 83964 MW; 1C221E57F73AB973 CRC64;
MITDTEHLKG LNKEQKEAAL HIKGPLLIVA GAGAGKTKTI THRIVNLIKN GVAPEKILAV
TFTNKAAKEM RDRIQTAIFS FDSRRGGENF PMRGVSQADG PRGSAPRARG DSDPAEEESS
TPFVSTFHSL GVHIIKENAR LLGLTRYFTI LDEGDAASLI KEIMKEIGID PKQYDPKKIK
NIISREKGKF THLSTYAESV NNTIGKIVAQ VWNLYEKRKM KENALDFDDL LLKAVKLLKD
NVEIRKVYQE KWEYIHVDEY QDTNEVQYLM SKLLSENNHN ICVVGDADQN IYSWRGANLK
NILSFEKDYP SAKIILLEQN YRSTKNILEA ANVIIKKNIY RPDKNLFTDN KIGEKIGLYE
ALDENDEADF VAIKILELLD GSVGSSFSQV LGNNPQTIRK STPGYAKENK AGVSLRGVSQ
ADGPRGSAPS ADGDSDPAET APARLSEVAI LYRANFQSRA LEEAMLRYNI PYQVLGVKFF
ERKEIKDTLA YLRAALNPNS LSDIKRIINF PARGIGKVTL AKIFAGNTES LPIKVKIKVY
NFYKVLEEIR EKIKTEKASR IIKFVVQHSG IENELSSGTE EDMERLENIK ELATLALKYD
NLANGLGVER LLEDAALASD QDSLMINTPH PDPLLGKERE NNAVKLMTVH ASKGLEFKYV
FVTGLEDGLF PHERQNEMQN GEDREEERRL FYVALTRAKE KLFLSFANFR TIFGSRNINT
PSEFIADIPP NLLQKEKEDS GIKTIYI
//
