ID A0A0G0WIR5_9BACT Unreviewed; 649 AA.
AC A0A0G0WIR5;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=UU18_C0013G0007 {ECO:0000313|EMBL:KKR75147.1};
OS Parcubacteria group bacterium GW2011_GWB2_40_8.
OC Bacteria.
OX NCBI_TaxID=1618890 {ECO:0000313|EMBL:KKR75147.1, ECO:0000313|Proteomes:UP000034552};
RN [1] {ECO:0000313|EMBL:KKR75147.1, ECO:0000313|Proteomes:UP000034552}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKR75147.1}.
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DR EMBL; LBZQ01000013; KKR75147.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0WIR5; -.
DR PATRIC; fig|1618890.3.peg.384; -.
DR Proteomes; UP000034552; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 14..301
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 302..556
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 35..42
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 649 AA; 73690 MW; 131D7B050CB8FF4C CRC64;
MCYYFFMIEN FLLDGLNEAQ KKVVLHKDGP LLVLAGAGSG KTKSITHRVA YLVSSGVAPE
NILAITFTNK AAGEMKERTL SLLKQIADNP TEQKNKTPFI STFHSLGVYM LKNSGKAVGV
TKGFSILDKE ESLGLIKEAI KELNIDPKQF QPSKMQSIIS KNKGELMSVD TYETDFAGDF
FPTMLAKIWR KYEEHLVAHK ALDFDDLVSK TVFLLKQDTA VREYYQNLWK YIIIDEYQDT
NKSQYEFSKI LAAKSKNICA VGDMDQCIYA FRGADFRNII NFENDYPDLV SVSLEENYRS
TQNILEAAAK IIEKNKVRKP KGLFTKNIKG AEISLFEAMG EQEEAEFVAH KIKELIREGV
EPSEIAVLFR ANFQSRVLEE ACLKHDVPYQ MLGTQFYDRK EIKDIFSYIK AALNREDAVS
IKRIINVPPR GLGKVSVLNK FAGKKLPVAT EAKFAEFNAL LDKIKESSEK ERPSSFIKFV
LRESGMQKFL ESGDPADAER LENVKELASI AARYDGLPLS EGVEKMVEDF ALMAAQDSLE
KKENSARLMT AHAAKGLEFA YVFITGLEDG LFPHSGMGNS VDKDEEERRL FYVALTRARK
KLFLTFSVMR MIFGSRQANM PSRFLSDIPE YLFKMEEFNR EVEDVIRYD
//
