ID A0A0G0X687_9BACT Unreviewed; 664 AA.
AC A0A0G0X687;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=UU78_C0059G0003 {ECO:0000313|EMBL:KKS20574.1};
OS Candidatus Roizmanbacteria bacterium GW2011_GWC2_41_7.
OC Bacteria; Candidatus Roizmanbacteria.
OX NCBI_TaxID=1618487 {ECO:0000313|EMBL:KKS20574.1, ECO:0000313|Proteomes:UP000034371};
RN [1] {ECO:0000313|EMBL:KKS20574.1, ECO:0000313|Proteomes:UP000034371}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKS20574.1}.
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DR EMBL; LCBY01000059; KKS20574.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0X687; -.
DR PATRIC; fig|1618487.3.peg.756; -.
DR Proteomes; UP000034371; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 18..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..240
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 327..575
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 664 AA; 74116 MW; 00004008E1B66C57 CRC64;
MRKIHLFSRD TQIHIRSFFI GIVAAIVFLF LPYFIYSWLK VLPNPSMLTR RDLEVSTKIY
DRNGSLLYEI YADQNRNPIP IGEIPKNIIQ ATIAIEDRDF YRHNGFSLKG ISRSLWEIIV
HHRIQGGSTI TQQLIKSALL TPDVTIVRKI KEIILAFWAE RMYTKNQILE MYFNQVPYGG
TAWGIESASH TYFGKSIKEL TLAESALLAG LPAAPSEYSP FGSHPEKAFF RQIEVLRRMK
EDGYVTQEEM DAAYKETIHF TTPNVSMRAP HFVMYIKDIL EKRYGTRLVQ QGGLRVVTSL
DVTIQEKMQD IVTSQINNLS YLQVGNGAAL VTNPKTGEIL AMVGSRNYFD TKQDGNVNVT
TSLRQPGSSI KVVTYALALE NGFTPATILD DSPVVYTYPG YPSYAPVNYD GKFHGPTPLR
YALGNSYNIP AVKLAAKLGV KQIIEKGRLM GIGSWIDESR YGLSITLGGG EVFMTDLAEV
FGTLANNGKR MDLIPILEVT DYTGKVYERI KEQRGIQAVK PEVAWIMSNI LSDNAARTNA
FGAQSTLVIP GKTVSVKTGT SNDKRDNWTI GYTQSVLAAV WVGNNDNTPM NPYLSSGVTG
AAPIWHDMMV ELLKDKQDEI PQRQDSIVSL PCYFGKPEYF IRGTEPAGGR CAPLPTITPT
PTPK
//
