ID   A0A0G0XTB7_9BACT        Unreviewed;       580 AA.
AC   A0A0G0XTB7;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:KKS27969.1};
GN   ORFNames=UU88_C0001G0071 {ECO:0000313|EMBL:KKS27969.1};
OS   Parcubacteria group bacterium GW2011_GWC1_42_11.
OC   Bacteria.
OX   NCBI_TaxID=1618905 {ECO:0000313|EMBL:KKS27969.1, ECO:0000313|Proteomes:UP000034518};
RN   [1] {ECO:0000313|EMBL:KKS27969.1, ECO:0000313|Proteomes:UP000034518}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA   Wilkins M.J., Williams K.H., Banfield J.F.;
RT   "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT   radiation of phyla.";
RL   Nature 0:0-0(2015).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKS27969.1}.
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DR   EMBL; LCCI01000001; KKS27969.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G0XTB7; -.
DR   PATRIC; fig|1618905.3.peg.73; -.
DR   Proteomes; UP000034518; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        48..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          137..201
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          246..553
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   580 AA;  64837 MW;  941D0937A4BAA063 CRC64;
     MSKRISQKYL KQLSRDINPD EIFLDSKNLP GFDKYQFEGR IEKPISHISI WGVFFSFLLI
     IFIFLAKVTI LQVVQGEEFL KKSENNRLSH TPLFAMRGVI YDRNKTPLAW NSFDDEEART
     ALIASETSTT TEKMPFPHRS YVTSSGFGHL LGYVSYPKRD SRGYYYQELF VGKDGIEEYY
     NEMLSGENGF QIIETDALGN SKEGSIVESP KNGTELTLSI DSRVQEKLYA TIRDTSNNFG
     YMAGAGAIID VENGELLAMT SYPEYESSTL SEGKNKKLIQ SYNLDKRAVF LDRAVSGVYT
     PGSIIKPFMA IAALAEGVIT PEKQILSTGS ISIQNPYYPN IKSVFNDWKA HGLVDMWRAI
     AVSSDVYFYA IGGGYEDQKG IGIANIEKYA RMFGFGELTG IDITDEKSGT IPNPEWKAKM
     FEDGVWRLGN TYHTVIGQYG FQTTLLQALR AVAGIANDGT LVTPHLLKDP TQEVSTSKIP
     ILQQHLQVAR EGMRQGVTSG TVTGLGVGYV SVAGKTGTAE IDAGKKYINS WVVGFFPYEK
     PRYAFAIVME RGPHDNTIGG VYVMRQMFDW MNQNTPEYIK
//