ID A0A0G0ZDA0_9BACT Unreviewed; 521 AA.
AC A0A0G0ZDA0;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=orotidine-5'-phosphate decarboxylase {ECO:0000256|ARBA:ARBA00012321};
DE EC=4.1.1.23 {ECO:0000256|ARBA:ARBA00012321};
GN ORFNames=UV09_C0014G0002 {ECO:0000313|EMBL:KKS46682.1};
OS Candidatus Gottesmanbacteria bacterium GW2011_GWA2_42_18.
OC Bacteria; Candidatus Gottesmanbacteria.
OX NCBI_TaxID=1618442 {ECO:0000313|EMBL:KKS46682.1, ECO:0000313|Proteomes:UP000034320};
RN [1] {ECO:0000313|EMBL:KKS46682.1, ECO:0000313|Proteomes:UP000034320}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP;
CC Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001419};
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 2/2. {ECO:0000256|ARBA:ARBA00004861}.
CC -!- SIMILARITY: Belongs to the OMP decarboxylase family. Type 2 subfamily.
CC {ECO:0000256|ARBA:ARBA00008847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKS46682.1}.
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DR EMBL; LCDD01000014; KKS46682.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G0ZDA0; -.
DR PATRIC; fig|1618442.3.peg.652; -.
DR UniPathway; UPA00070; UER00120.
DR Proteomes; UP000034320; Unassembled WGS sequence.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR011995; OMPdecase_type-2.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR02127; pyrF_sub2; 1.
DR PANTHER; PTHR43375; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR PANTHER; PTHR43375:SF1; OROTIDINE 5'-PHOSPHATE DECARBOXYLASE; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239}.
FT DOMAIN 337..520
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
SQ SEQUENCE 521 AA; 57835 MW; 9D857872D880BAEC CRC64;
MMPTEVLQIP DRKNPVIEKI ERRWESVNSM AGVGLDPDVS RIPGEIWDIT GRENIADGIF
LFNKRIIDVT APYVVDFKIN SNFYQGVEGR DALARTFAYL KHTYPDIVRI YDGKFADVGH
TSEQIATEVF ERIDADAILL NPYLGFDGIE PFTRHADKLS ILCVNTSNPS ASDIQELVLA
DGTILWRRVL DIAMNNWNKN GNIIPVLSAT HSGNLSGIRS AIGQRPILLA GIGVQGGDIE
ATLEDCLNDD KFGVMISSSR AILYPEIAEG ETYFHASERA IKELRDRINA AKSVILDKEI
MGAEQLLGAD FSGEASLEAT ADLHQRPEEI AELDVNKLFV LLLGPSGVGK STLIRILTLL
SDKFQYVRPC TTRPLREGET DKDFVDETEF DRIATEGGFA SVNYMYGAKY GLRTSSITEA
IAAGKIPILD FPLDKARQLE RPEYSLLRIY IFPEGITQWL QRLREAGRDS DGRTEMGLEE
LEVLVNMTTP HPDIHFSVIN AENRQTDTAG IIVGLTDSLG N
//
