ID A0A0G1A6N7_9BACT Unreviewed; 782 AA.
AC A0A0G1A6N7;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=UV20_C0009G0068 {ECO:0000313|EMBL:KKS56589.1};
OS Candidatus Magasanikbacteria bacterium GW2011_GWA2_42_32.
OC Bacteria; Candidatus Magasanikbacteria.
OX NCBI_TaxID=1619039 {ECO:0000313|EMBL:KKS56589.1, ECO:0000313|Proteomes:UP000034837};
RN [1] {ECO:0000313|EMBL:KKS56589.1, ECO:0000313|Proteomes:UP000034837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKS56589.1}.
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DR EMBL; LCDO01000009; KKS56589.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1A6N7; -.
DR PATRIC; fig|1619039.3.peg.977; -.
DR Proteomes; UP000034837; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 5..310
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 311..606
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 26..33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 782 AA; 88928 MW; 6423BC34AD8C790A CRC64;
MSSSPTLNQA QSQAVTHDNG PLLIVAGAGT GKTTVIAQRL AWLIEQKLAK PNEILALTFT
DKAAGEMEER VDALLPYGFL DLWVQTFHAF GERLLKAHGL DIGLSNDFKL LTPTDAWLLV
RENLDKFDLD YYRPLGNPTK FIHAMIRHFS RCKDEMVTPD EYIKYAENLV LDSDSALGDA
KEILGDEKKR LYEIANAYHT YNQILLDNNA LDFGDLINYT LKLFQTRPKI LETYRRQFKY
ILVDEFQDTN LAQYELIKIL SAPLQNLTVV GDDDQAIYKF RGASISNILH FKNDYPNAKL
VTLTENYRSA QSILDKAYQL IINNNPDRLE EKLKINKKLI AKKTITGQIE EIHANTGIEE
ARQVVEKIQT LKLADEKAKL ESSWNDFAIL IRSNATADSF MHALEQAGVP FQFLASKGLY
REGLVLDIIS YLKLLDNYHE NPAMWRVLNM PFWNIATEDI VKITHQAKKK TWSIFETLKH
ASALGVGETG IKNIEKMLGL LAKHAELARY ESVGKVAYAF LNDSGYLKNL VTKSAEGVSE
SMRQIMFLKQ YYDTIIKFEE SNAEKLTKHY LAYLHYVLES GEEGSLRGTD EDPEAVKIMT
VHSAKGLEFK HVFLVNLVEQ KFPSTNRSES IELPDKLVKE ILPEGDIHLQ EERRLFYVGL
TRAKESVFFC HADDYGGTRK RKPSRFLNEL NLPVNVIPAK AGIQKNPLDS RFRENDNKKN
ILAPNAVIPP HFSFTQLKAF ATCPLQYRFA HILHIPVKGS ASFSFGKKSN TNPFIGRSFN
FL
//
