ID   A0A0G1AU01_9BACT        Unreviewed;       498 AA.
AC   A0A0G1AU01;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00020675, ECO:0000256|RuleBase:RU000644};
GN   ORFNames=UV33_C0023G0005 {ECO:0000313|EMBL:KKS64580.1};
OS   Candidatus Daviesbacteria bacterium GW2011_GWA1_42_6.
OC   Bacteria; Candidatus Daviesbacteria.
OX   NCBI_TaxID=1618420 {ECO:0000313|EMBL:KKS64580.1, ECO:0000313|Proteomes:UP000034135};
RN   [1] {ECO:0000313|EMBL:KKS64580.1, ECO:0000313|Proteomes:UP000034135}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA   Wilkins M.J., Williams K.H., Banfield J.F.;
RT   "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT   radiation of phyla.";
RL   Nature 0:0-0(2015).
CC   -!- FUNCTION: One of the essential components for the initiation of protein
CC       synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC       and promotes its binding to the 30S ribosomal subunits. Also involved
CC       in the hydrolysis of GTP during the formation of the 70S ribosomal
CC       complex. {ECO:0000256|RuleBase:RU000644}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC       superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC       {ECO:0000256|ARBA:ARBA00007733, ECO:0000256|RuleBase:RU000644}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKS64580.1}.
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DR   EMBL; LCEB01000023; KKS64580.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G1AU01; -.
DR   PATRIC; fig|1618420.3.peg.283; -.
DR   Proteomes; UP000034135; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd01887; IF2_eIF5B; 1.
DR   CDD; cd03702; IF2_mtIF2_II; 1.
DR   CDD; cd03692; mtIF2_IVc; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.40.30.10; Translation factors; 2.
DR   Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR   InterPro; IPR044145; IF2_II.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR   InterPro; IPR000178; TF_IF2_bacterial-like.
DR   InterPro; IPR015760; TIF_IF2.
DR   InterPro; IPR023115; TIF_IF2_dom3.
DR   InterPro; IPR036925; TIF_IF2_dom3_sf.
DR   InterPro; IPR009000; Transl_B-barrel_sf.
DR   NCBIfam; TIGR00487; IF-2; 1.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR43381:SF5; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR   Pfam; PF00009; GTP_EFTU; 1.
DR   Pfam; PF11987; IF-2; 1.
DR   PRINTS; PR00315; ELONGATNFCT.
DR   SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50447; Translation proteins; 2.
DR   PROSITE; PS51722; G_TR_2; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW   ECO:0000256|RuleBase:RU000644};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU000644}.
FT   DOMAIN          4..199
FT                   /note="Tr-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51722"
SQ   SEQUENCE   498 AA;  53728 MW;  CF8FADF326BF5762 CRC64;
     MEQLRPPVVT ILGHVDHGKT TLLDFIRKTS VAAKEHGGIT QAIGAYQARV QGTGDSGQKE
     KKSSLQPETS NLITFIDTPG HAAFEKMRSR GAEACDIAVL VVAVEDGVMP QTVEAIKHIQ
     SAGIPMIVAV NKVDLPGVDV KVQLEKIKKQ LSDQKVLVEE YGGDVPIVPI SAKTGQGVED
     LLETINLVAE IHEFKGNPEL LALGVIIESR VDKFKGAIAT VLVRDGTLKK GDNLMVGGVK
     GKVRGMFDFA GRAVDLAGPS VPVEVLGFES VPPVGAKLGE EKKAETEGRK TVSLIDKLRA
     GETQTLNVVI RADKQGSLEA VEDILQKLDP EHIKIIASGT GDINDSDVEL AASAKGIILG
     FNVSVIHTAQ KFAETERILI RTYNIIYELT EELEEVVEAM LKPGKVEEVF GKAQILAEFP
     YGKSEKVAGC KILEGTFSKG PKVRIVRGEE IIGEAKIKSL KKVKEEVPKV EKGQECGMMF
     DPGIDFQIGD IVESFRTF
//