ID A0A0G1AWA1_9BACT Unreviewed; 460 AA.
AC A0A0G1AWA1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Radical SAM domain protein {ECO:0000313|EMBL:KKS65307.1};
GN ORFNames=UV33_C0006G0002 {ECO:0000313|EMBL:KKS65307.1};
OS Candidatus Daviesbacteria bacterium GW2011_GWA1_42_6.
OC Bacteria; Candidatus Daviesbacteria.
OX NCBI_TaxID=1618420 {ECO:0000313|EMBL:KKS65307.1, ECO:0000313|Proteomes:UP000034135};
RN [1] {ECO:0000313|EMBL:KKS65307.1, ECO:0000313|Proteomes:UP000034135}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKS65307.1}.
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DR EMBL; LCEB01000006; KKS65307.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1AWA1; -.
DR Proteomes; UP000034135; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485}.
FT DOMAIN 1..134
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 189..425
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 460 AA; 52097 MW; B0EF49AFF149DB37 CRC64;
MKIVLVRPNY KSHIITPPLG IGYLASSLKK HSINVKIIDG LREGTGHDAL LQKIVSEKPD
AVGITCLTSF YNEVIELSKA LKEKGYKVII GGVHPTFLPL ETITDSKADY VVCGEGEIAL
VKLAKNKFVN KQSFSSNKNI PGVYSKKDLE SGKPIIKAEA AKILDDLPFP DWKQLDPNTY
PKAPHGAFVK NFPIGVIMTT RGCPYLCTFC ASRKFYDVKI RYRTPENVIE EIKYLIKNFG
IKEVHFEDDN LTLKRDHVEK ICNLILENNL KISWACPNGI RADKVDEDLI KLMKKSGCYF
FAFGIESASP KILKNIKKLE TISVIKKSIE IASKVGIECQ GFFIFGLPGE TMKTIDESIE
FAKSSKLSRA HFMILDVLPG SELWGQLSGK FKPDWGKDSY REPEWIPKGL TKNILMDAQS
RAIREFYFRP ATLFRILRSI KPRQLKFLIQ RFTAYRIYGN
//
