ID A0A0G1CBE1_9BACT Unreviewed; 1052 AA.
AC A0A0G1CBE1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=UV58_C0004G0040 {ECO:0000313|EMBL:KKS82867.1};
OS Candidatus Wolfebacteria bacterium GW2011_GWC1_43_10.
OC Bacteria; Candidatus Wolfebacteria.
OX NCBI_TaxID=1619011 {ECO:0000313|EMBL:KKS82867.1, ECO:0000313|Proteomes:UP000034810};
RN [1] {ECO:0000313|EMBL:KKS82867.1, ECO:0000313|Proteomes:UP000034810}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKS82867.1}.
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DR EMBL; LCFA01000004; KKS82867.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1CBE1; -.
DR PATRIC; fig|1619011.3.peg.192; -.
DR Proteomes; UP000034810; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..71
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1052 AA; 119465 MW; 363B8C8FB6A5E381 CRC64;
MNFVHLHTHS HYSLLDGLAK IDDLISQAKR LGMTALALTD HGNLYGAVEF YKKAKKEGIK
PILGVEAYLA PKSRLEKNPD EKYYHLTLLA KNNQGWKNLI QLVTKANLEG FYYKPRIDKE
LLRQHSQGLI AFSGCPSGEI PRFLAKGKKE EAREALNFYK EVFGENFYIE IWHQPKIKEM
EEVIPLLVEL AQKENVPLVA TQDIHYIRKD DSFFHDILLA VQTGNRITDD DRLTLKAGEF
FMRSPEEMAQ GFSPWPQALE NTVKIAESCN VEIPLGKTIL PHFPIPEGET SFSFLKKLID
QRIKERYQEI APEIKDRLEY ELGVIEKTGF ADYFLIVQDF VNWAKERKIV VGPGRGSAAG
SLVSYILKIT EVDPIKYNLL FERFLNPDRV QMPDIDLDFT DIRRDEVMGY LRQKYGEDHV
AHIITFGTMA SRASVRDAGR ALGFSYGFCD QIAKLIPFNL KLDDALNQIE DFKKMYQENT
DARKLVDAAR HLEGVARHAS VHACGIVISK EPLTEYLPLQ FAPQDTNTII TQFEMYTIED
LGLLKIDLLG LKNLTIIEDT IRTVKDIQNI TLDISKIPLD DPKTFKTLQA ADTTGVFQLE
SSGVRRYLKE LVPTELEDIV AMVSLYRPGP MELIPHYITR KQGKEKVVYL HSKLEPILSR
TYGIGIYQEQ MMQIARDLAG FTLSEADILR KAIGKKIKEL LDQQKEKLTS GMIENGIDKE
TAEKIWELFP PFARYGFNRS HAVCYALIAY QTAYLKTHFP VEFMTAIFNA DIGDVERAAF
LVSEAKKMKV KVLPPDINQS YSVFVPEGNN IRFGLSAIKN VGSNIVDAII EKRQKGGPFE
RFEDFLSRVT HKDLNKKSLE SLIKAGVFDS LNIERSSLLA NLDKILSFAL GIRKNSNGSQ
SNLFGSHLNP AKLVLEKVPP PTKEEKLFWE KELLGFYISD HPLKKYEKMF EEKKVHPIGK
VIEYIGSGKG TGSVRTGGII ATVKKIISKN QKPIVFAKIE DLSDTLEVVV FSDVLEKNPS
IWEEKNIVVV QGKPSLRDNE PKIIVDQVIK LN
//