ID A0A0G1E0E4_9BACT Unreviewed; 172 AA.
AC A0A0G1E0E4;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN ORFNames=UV50_C0019G0010 {ECO:0000313|EMBL:KKS76571.1};
OS Parcubacteria group bacterium GW2011_GWB1_42_9.
OC Bacteria.
OX NCBI_TaxID=1618871 {ECO:0000313|EMBL:KKS76571.1, ECO:0000313|Proteomes:UP000034249};
RN [1] {ECO:0000313|EMBL:KKS76571.1, ECO:0000313|Proteomes:UP000034249}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004903}.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00009539}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKS76571.1}.
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DR EMBL; LCES01000019; KKS76571.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1E0E4; -.
DR PATRIC; fig|1618871.3.peg.652; -.
DR UniPathway; UPA00077; UER00158.
DR Proteomes; UP000034249; Unassembled WGS sequence.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
FT DOMAIN 3..172
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 172 AA; 19522 MW; 1C3ADBE7DCC225E9 CRC64;
MKKISMVVAT DRSGIIGCDG QLPWDIPIDR RRFKNLTMGH PVIMGRKTFE SIDPRFRPLP
GRTNIVLSQT MTDVEKVVVA RDISQALQMA ESAPGNEEIF VIGGHSVYRD FLPFTNRIYW
TLVGMDCHLD TERTYVRFPT SLLSSGWKMG KFEMPDSGSA DRPAIAFFTF DR
//
