ID A0A0G1FBE3_9BACT Unreviewed; 1069 AA.
AC A0A0G1FBE3;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 13-SEP-2023, entry version 28.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=dnaE {ECO:0000313|EMBL:KKS92451.1};
GN ORFNames=UV67_C0003G0003 {ECO:0000313|EMBL:KKS92451.1};
OS Parcubacteria group bacterium GW2011_GWC1_43_12.
OC Bacteria.
OX NCBI_TaxID=1618909 {ECO:0000313|EMBL:KKS92451.1, ECO:0000313|Proteomes:UP000034170};
RN [1] {ECO:0000313|EMBL:KKS92451.1, ECO:0000313|Proteomes:UP000034170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKS92451.1}.
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DR EMBL; LCFJ01000003; KKS92451.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1FBE3; -.
DR STRING; 1618909.UV67_C0003G0003; -.
DR PATRIC; fig|1618909.3.peg.78; -.
DR Proteomes; UP000034170; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000313|EMBL:KKS92451.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KKS92451.1}.
FT DOMAIN 4..71
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1069 AA; 120868 MW; A469EA686A83652F CRC64;
MKFTHLHVHS HYSLLDGLPK IDGLVNRALE LGMDSLALTD HGSIYGAVEF YKKAKAKGLK
PIIGSEMYIT PESRFNKRGR MDDKRFHLLI LVKDKIGYQN LVKLTTKAWL EGFYYKPRID
KEILRQHSQG LIASSACLAG EISRAIVNNE TTDKAEAIAL EYLEIFGAGN FYLEIEHHPR
LPDQKRVNDA LIKMSVKLGI PLVATHDVHY LNPDDARAQD ILMLVNTNAN IDDPERLTLL
ADDFSLRPQE DMIEWFKDTP QAIESTQKIA ADCNFEFELG KYQLPYFDVP KEYNPETYLR
HLCEIGMEKR YPEGTNEKIL ARLEHELNII QKTGFASYFL IVQDFTNWAK NNKIVVGPGR
GSAAGSLVAY LLNITEIDPL KYDLLFERFL NPERISMPDI DMDFADRRRE EVIEYVRQKY
GTDHVAQIIT FGTMAARAAI RDSGRAMGYA YTLCDQVAKA IPIAVGMTLK KALDQSAEFK
QLYESDDQIK KLVDTALKLE GVARHASTHA AGVVITKDPL DSVVALQHPT QDDDAIVTQY
EMHGIEDLGL LKMDFLGLKT LTQIENALEI IEKTKGEKIE IISLPLDDEK TYQLLRDAKT
TGVFQLESGG MKRNLKELKP TVFEDIIAMV ALYRPGPMDF IPDFIAHKHG AKKIEYIHPS
LEPILKNTYG IVIYQEQVME IACKLAGYTL PEADMLRKAV GKKIKKLMDE QRGKLVEGMV
KNNIERETAE KIWDFIEPFA RYGFNKAHAT CYALVGYQTA YLKAHYPTEL MAALMNSESD
DIERIAFLIE ECRQMGIDVL APHINESLGS FTVIKDNVIR FGLNAIKNVG GNIVEAIVKE
RKKNGLFESI SDLVERVQDK DLNKKSLESL AKCGALDCLS ERGQILGNIQ LILNFAKEVQ
KPKNTGQSSL FSLPAADGKK NGLMPSLKLL PAPESAKRDR LSWEKELLGL YISEHPVQEY
EKVIESMATL PSKIIPQWVG RNLKVGGAIT KIHKIITKTG KPMLFVTLED RRSKVEVLVF
PKTLERTATF WQEDKIAVVS GRLDDKEGNY KILCESAQEL NQNHLRNFR
//
