ID A0A0G1KHX9_9BACT Unreviewed; 420 AA.
AC A0A0G1KHX9;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=prephenate dehydratase {ECO:0000256|ARBA:ARBA00013147};
DE EC=4.2.1.51 {ECO:0000256|ARBA:ARBA00013147};
GN ORFNames=UW39_C0009G0039 {ECO:0000313|EMBL:KKT47504.1};
OS Parcubacteria group bacterium GW2011_GWC2_44_17.
OC Bacteria.
OX NCBI_TaxID=1618929 {ECO:0000313|EMBL:KKT47504.1, ECO:0000313|Proteomes:UP000034811};
RN [1] {ECO:0000313|EMBL:KKT47504.1, ECO:0000313|Proteomes:UP000034811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O;
CC Xref=Rhea:RHEA:21648, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:18005, ChEBI:CHEBI:29934; EC=4.2.1.51;
CC Evidence={ECO:0000256|ARBA:ARBA00000913};
CC -!- PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis;
CC phenylpyruvate from prephenate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004741}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKT47504.1}.
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DR EMBL; LCIC01000009; KKT47504.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1KHX9; -.
DR STRING; 1618929.UW39_C0009G0039; -.
DR UniPathway; UPA00121; UER00345.
DR Proteomes; UP000034811; Unassembled WGS sequence.
DR GO; GO:0004664; F:prephenate dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0009094; P:L-phenylalanine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd04905; ACT_CM-PDT; 1.
DR CDD; cd13630; PBP2_PDT_1; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR001086; Preph_deHydtase.
DR InterPro; IPR018528; Preph_deHydtase_CS.
DR PANTHER; PTHR21022; PREPHENATE DEHYDRATASE P PROTEIN; 1.
DR PANTHER; PTHR21022:SF19; PREPHENATE DEHYDRATASE-RELATED; 1.
DR Pfam; PF01842; ACT; 1.
DR Pfam; PF00800; PDT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS00857; PREPHENATE_DEHYDR_1; 1.
DR PROSITE; PS51171; PREPHENATE_DEHYDR_3; 1.
PE 4: Predicted;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Aromatic amino acid biosynthesis {ECO:0000256|ARBA:ARBA00023141};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Phenylalanine biosynthesis {ECO:0000256|ARBA:ARBA00023222}.
FT DOMAIN 2..176
FT /note="Prephenate dehydratase"
FT /evidence="ECO:0000259|PROSITE:PS51171"
FT DOMAIN 194..277
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 420 AA; 48137 MW; C5E3B42231D26F65 CRC64;
MNLYYLGPAG SFTEEAAKNF IEEAMYIPCS SIEDTLAAVK TNPNSLCVVP VENSLEGTVL
RTLDLILEKN LRVIAEIDLL ISQNLLSKEK TLSAIQTVYS HQHAIAQCRV WLKKHLPNAE
YKETSSTSYA AELVSKMPGA AAISSLHAAD LYHLNVLGSH INNHAHNLTR FWLVTKMTHT
ALPIWTNRTP TKTSLYIVLK DKVGALRDLL ETFAKNNVSL TFIESRPLAS KPWCYGFFID
ILVDASDPFA RKMFAALKKE HLKAHLIGTY PQDRAYNKKS TIARNLKRIE HIFEKNRRSP
LIRTILDEAR NEWHNYQQTP RRVQRLLDTR FLLIPSIALN KYKSGDGLTD RLRERALLQK
TRHSAILHLL YGELFKRSKQ TQEKIIRLIK TKSILSEDIL KLSLNDVRYY IDYIDTLIIQ
//
