ID A0A0G1LH55_9BACT Unreviewed; 911 AA.
AC A0A0G1LH55;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=UW95_C0003G0033 {ECO:0000313|EMBL:KKT95191.1};
OS Parcubacteria group bacterium GW2011_GWC1_45_14.
OC Bacteria.
OX NCBI_TaxID=1618915 {ECO:0000313|EMBL:KKT95191.1, ECO:0000313|Proteomes:UP000034654};
RN [1] {ECO:0000313|EMBL:KKT95191.1, ECO:0000313|Proteomes:UP000034654}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKT95191.1}.
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DR EMBL; LCKI01000003; KKT95191.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1LH55; -.
DR STRING; 1618915.UW95_C0003G0033; -.
DR PATRIC; fig|1618915.3.peg.255; -.
DR Proteomes; UP000034654; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:KKT95191.1};
KW Hydrolase {ECO:0000313|EMBL:KKT95191.1};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nuclease {ECO:0000313|EMBL:KKT95191.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 325..576
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 911 AA; 104405 MW; 7A53C95B24943577 CRC64;
MAKTSYNERS WAIDLISEIN AYSSAKNKTI DRAGGETTIN TGKKRLFPDV LLYGRNSEIL
MGWELKMPDT LVTDEEFIKN AILKANILGL NSFLLWNVGV AVLYVKKDNE FEPAKLWDSL
KKSITTRDKV DEFKDEWKKL LQEILKDLNA FFESGFIEKK TFIESFKDSE IVDFILRNDT
GVAENLKKAA TKDARFSAEA NIWWRVAKLD YPQQNQWEIL SKIILINWIN KILFAHILIA
FFDPAKKIEL IKDETSVEEA EIIFQEISAE CNFWNIFQPQ LGENYLTDES WSEIIQLNVL
LNNVELSSVG QELLQELLQD IIYSSKRKIA GQYATPMFLA RLLTGLVMLN KELTFHDPCC
GTGTIARCAY DIKKESGISS KDSLKTIFSS DKVAFPLQMA TIALTEPVNI GEIIQIFKED
CTNVFIGQDI EFKDPYTGKP VVKKYEGVNY IASNLPFIQQ EDLEILNPNI KENTREIFEN
LLGENLSLKA KSDLYAYIPF YLWKILKTGG RLGIITSNSW LGTEWGSAFK VALNKFYHIE
SILISGKGRW FNNADVVTTI LILNRRNLLN EINEDEVTNF ITIDFDLQKE TDNQKVGEVL
ENVLAGLSSE HVIIRKYKTK ELSDFTLNWS ALFSDVSWLK DIENKLILAS NLFDINRGER
RGWDAMFYPE SGHNIEAEYL QPVLKSSRDI NMLVTQAESE SFCCSESLEN LQKLGHTGAL
NWIRKFEHEF NTSGDKLLPD ALKRAGYFWY EMNNSTMADL VTSMNFDKRI FVAKLEKRSF
VNQRLTRFTA KNIDIDIDLS QALLNSVLGI FFIEALGFGR GLGALDLSST RMKNSLQILN
SDLLSDKQKD DIKKKFAVLK NREILPILDE LRSSDRKEFD DVVFDAFGIS EYRDNIIGSL
KTLYNIRKNI F
//
