ID   A0A0G1NQI8_9BACT        Unreviewed;       497 AA.
AC   A0A0G1NQI8;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   22-FEB-2023, entry version 16.
DE   RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN   ORFNames=UW85_C0001G0022 {ECO:0000313|EMBL:KKT86474.1};
OS   Parcubacteria group bacterium GW2011_GWA1_Parcubacteria_45_10.
OC   Bacteria.
OX   NCBI_TaxID=1618789 {ECO:0000313|EMBL:KKT86474.1, ECO:0000313|Proteomes:UP000034745};
RN   [1] {ECO:0000313|EMBL:KKT86474.1, ECO:0000313|Proteomes:UP000034745}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA   Wilkins M.J., Williams K.H., Banfield J.F.;
RT   "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT   radiation of phyla.";
RL   Nature 0:0-0(2015).
CC   -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC       D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the lactate permease family.
CC       {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKT86474.1}.
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DR   EMBL; LCJX01000001; KKT86474.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G1NQI8; -.
DR   PATRIC; fig|1618789.3.peg.23; -.
DR   Proteomes; UP000034745; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR003804; Lactate_perm.
DR   PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR   PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR   Pfam; PF02652; Lactate_perm; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU365092};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM        6..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        61..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        178..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        209..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        238..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        283..304
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        310..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        353..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        402..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        438..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        478..496
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
SQ   SEQUENCE   497 AA;  53524 MW;  CACADD0FEDE68351 CRC64;
     MTQALTFLVS LSPFAVFIYL LLKKNLALAK TSFVTLGLTL ALAFFYWRIV PQAAFVSLGK
     GFFVAFDIFV ILGGAIFFLE ILKRFGVIEA VSYYLESFSK DHRIQVILLA WFLENFIEGT
     AGFGTPSAIV APLLVGLGLA PLNAAIVSLF GNSSSVVFGA AGTPIRIGFF GLESSSVPFY
     AAMINIVGLI VPLFMLWTVV SHRQDRKKLF WEAVPFAIWS GLAFVLPSIL VVPLGQEFPS
     IIGAIIGVLL VFVSTKLGIF VPKNAMTVRP EEKLQTKLSL RKTVFPYGLL VLLLVLGKIF
     LSGISFKIPL INHSISAFNP GLAFILAGIL VVAAWRKTEK LVLRTAVFSL RQAVGPFLVI
     IAMSAMVQLM INSGQNFSSL PSLIAIVAKT FETSWLPFFS PFVGAFGSFL TGSATISNLL
     FGGFLAQAAF ELSMNSQIIL ALALVGGAAG NMIALADMLA AETVVGLKNK EAEIIKKIFV
     PCLIYVLLAG IIGMVIV
//