ID A0A0G1QD55_9BACT Unreviewed; 772 AA.
AC A0A0G1QD55;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=UX24_C0032G0006 {ECO:0000313|EMBL:KKU15668.1};
OS Candidatus Giovannonibacteria bacterium GW2011_GWB1_45_9b.
OC Bacteria; Candidatus Giovannonibacteria.
OX NCBI_TaxID=1618653 {ECO:0000313|EMBL:KKU15668.1, ECO:0000313|Proteomes:UP000034020};
RN [1] {ECO:0000313|EMBL:KKU15668.1, ECO:0000313|Proteomes:UP000034020}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC family. {ECO:0000256|ARBA:ARBA00008263}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKU15668.1}.
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DR EMBL; LCLL01000032; KKU15668.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1QD55; -.
DR PATRIC; fig|1618653.3.peg.435; -.
DR Proteomes; UP000034020; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00187; TOP4c; 1.
DR Gene3D; 3.30.1360.40; -; 1.
DR Gene3D; 2.120.10.90; DNA gyrase/topoisomerase IV, subunit A, C-terminal; 2.
DR Gene3D; 3.90.199.10; Topoisomerase II, domain 5; 1.
DR Gene3D; 1.10.268.10; Topoisomerase, domain 3; 1.
DR InterPro; IPR006691; GyrA/parC_rep.
DR InterPro; IPR035516; Gyrase/topoIV_suA_C.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013758; Topo_IIA_A/C_ab.
DR InterPro; IPR013757; Topo_IIA_A_a_sf.
DR InterPro; IPR002205; Topo_IIA_dom_A.
DR PANTHER; PTHR43493:SF5; DNA GYRASE SUBUNIT A, CHLOROPLASTIC_MITOCHONDRIAL; 1.
DR PANTHER; PTHR43493; DNA GYRASE/TOPOISOMERASE SUBUNIT A; 1.
DR Pfam; PF03989; DNA_gyraseA_C; 5.
DR Pfam; PF00521; DNA_topoisoIV; 1.
DR SMART; SM00434; TOP4c; 1.
DR SUPFAM; SSF101904; GyrA/ParC C-terminal domain-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 11..465
FT /note="DNA topoisomerase type IIA"
FT /evidence="ECO:0000259|SMART:SM00434"
FT COILED 437..485
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 772 AA; 86369 MW; 0400BF0AB4EA09C5 CRC64;
MAEENKNIQK RDIIPEMRES YLDYAMSVIV SRALPDVRDG LKPVHRRILH TMNEMGLRHN
AKYRKSAAVV GDTLGKYHPH GDMAVYDSIV RMAQDFSMRY TLVDGQGNFG SIDGDNAAAP
RYTEIRMTQI AEELLGDIEK ETVEFRDNYD GTRKEPVVLP AALPNLLLNG TLGIAVGMAT
NIPPHNLGEA IDAASHLIGH PRATTEDLME FIKGPDFPTG GLIFSKKDLL QAYSTGRGSI
LTRGEAEIVE KSKGNFQIII SSIPYQVNKS ELIIKMADLV REKRIDGIRD IRDESDKEGL
TIAIDLKHDA VPEKILNGLY KFTDLERAFH FNMIALVDGI QPQVLSLKSI LENFVSWRKI
IVERRAKFDL KKAEERAHIL EGLKKALDHI DAVIKTIRAS ESKEDAHKNL VKKFDLSVKQ
ADAILEMRLQ TLAGLERQKI DNELKEKQKL IRDLKSLLKD PDKIAETVKN ELLELKKKYA
DSRKSKIIAS EVKSFSMEDL IPEKETIVVL TQDGYIKRVN PEEYRSQKRG GKGIIGHETK
EEDIVTNFFS GNTHDDLLLT KKGEVLSLVM ITRGGIIKKV DSKHFEDVRR SGIIAIKLQK
DDLLFWVRLA QKGDHIILTT KKGQAIRFKE TDARQMGRSA QGVRAMRLKK GDELVGADII
SAKEKPARPA GGDALILVVS ENGFGKKTKI SEYRLQKRGG SGIKTSKVTP KTGNLVSAKV
LSPDLEEIIA ISKKGQVIRT SLKEISELGR ATQGVRIMRL DSKDKLASIT CL
//
