ID A0A0G1SND5_9BACT Unreviewed; 557 AA.
AC A0A0G1SND5;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Sodium/hydrogen exchanger {ECO:0000313|EMBL:KKU71019.1};
GN ORFNames=UX95_C0006G0014 {ECO:0000313|EMBL:KKU71019.1};
OS Candidatus Woesebacteria bacterium GW2011_GWD1_47_21.
OC Bacteria; Candidatus Woesebacteria.
OX NCBI_TaxID=1618594 {ECO:0000313|EMBL:KKU71019.1, ECO:0000313|Proteomes:UP000034575};
RN [1] {ECO:0000313|EMBL:KKU71019.1, ECO:0000313|Proteomes:UP000034575}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKU71019.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LCOD01000006; KKU71019.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1SND5; -.
DR PATRIC; fig|1618594.3.peg.148; -.
DR Proteomes; UP000034575; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 28..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 50..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..130
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 350..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 404..526
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 557 AA; 60282 MW; E71A131F5AED80DC CRC64;
MSFAELALLL VVAAAAGVVA KTLKQPLLIG YLFAGLLLAF FGVVRDFEAI AALGKIGVAL
LLFLVGLEMN VRELPTIGKV ALMTGLGQII FTSVVGYLIS LALGFGVLPS IYIAVALTFS
STIIIVKLLS EKGDIGSLYG KIAVGFLLVQ DFVAILILMF LAGVGRGEVN PGQFFLIAIK
AIALLASVWF LSKKILPAFF DKFIASSPEI LFVGSIAWAL GVAALVGGPL GFSYEIGGFL
AGLALSNLPE HLGIASKTRP LRDFFLTIFF LTLGTQLLVK NIGVVIAPAV IFSLFVLIGN
PLIVLIIMGV MRYKKRTSFL ASVTVAQISE FSFILMAMGL TLGHVSQAEV ATVILVGVIT
MTISTYLILA SDKIFLKLKD VLSIFERRLT HETALLEEKI YNDHIVLIGC DKMGKTLISF
FKKKGLLYLV VDHNPKVFAN LSAERIPVLL GDIDDPEIKA LAKMDKARMV ISTISNTSDN
LSILEYIRNL TRRPLAITKA TSKGDALKEY EAGASFVLLP EVIAGEYLRH IFVSHGISDE
RIRKMGKGHF NRLLTSR
//
