ID A0A0G1TLZ4_9BACT Unreviewed; 148 AA.
AC A0A0G1TLZ4;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=tRNA (guanine-N(1)-)-methyltransferase {ECO:0000256|RuleBase:RU003464};
DE EC=2.1.1.228 {ECO:0000256|RuleBase:RU003464};
DE Flags: Fragment;
GN ORFNames=UY10_C0022G0010 {ECO:0000313|EMBL:KKU82831.1};
OS Microgenomates group bacterium GW2011_GWA2_47_8.
OC Bacteria.
OX NCBI_TaxID=1618503 {ECO:0000313|EMBL:KKU82831.1, ECO:0000313|Proteomes:UP000034016};
RN [1] {ECO:0000313|EMBL:KKU82831.1, ECO:0000313|Proteomes:UP000034016}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- FUNCTION: Specifically methylates guanosine-37 in various tRNAs.
CC {ECO:0000256|RuleBase:RU003464}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-
CC methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:36899, Rhea:RHEA-COMP:10145, Rhea:RHEA-COMP:10147,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:73542, ChEBI:CHEBI:74269; EC=2.1.1.228;
CC Evidence={ECO:0000256|RuleBase:RU003464};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU003464}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU003464}.
CC -!- SIMILARITY: Belongs to the RNA methyltransferase TrmD family.
CC {ECO:0000256|RuleBase:RU003464}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKU82831.1}.
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DR EMBL; LCOS01000022; KKU82831.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1TLZ4; -.
DR PATRIC; fig|1618503.3.peg.489; -.
DR Proteomes; UP000034016; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0052906; F:tRNA (guanine(37)-N1)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR002649; tRNA_m1G_MeTrfase_TrmD.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR InterPro; IPR016009; tRNA_MeTrfase_TRMD/TRM10.
DR NCBIfam; TIGR00088; trmD; 1.
DR PANTHER; PTHR46417; TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR46417:SF1; TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE; 1.
DR Pfam; PF01746; tRNA_m1G_MT; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU003464};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003464};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|RuleBase:RU003464};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003464};
KW tRNA processing {ECO:0000256|RuleBase:RU003464}.
FT DOMAIN 23..148
FT /note="tRNA methyltransferase TRMD/TRM10-type"
FT /evidence="ECO:0000259|Pfam:PF01746"
FT NON_TER 148
FT /evidence="ECO:0000313|EMBL:KKU82831.1"
SQ SEQUENCE 148 AA; 16581 MW; E87FFBF5BF7EEFF8 CRC64;
MHITILTLFP EMFVGPFDHS IVKRAKQKGL LTINIVNIRD YATDKHKSVD DRPYGGGTGM
IMRVDVIDRA IKEQKHVLKE KTIFLDPKGT PYTQAKAREL SRFDHLILIC GHYEGVDERV
SALVDESISV GDYILTGGEI PAMVLVDS
//
