ID A0A0G1UYP1_9BACT Unreviewed; 329 AA.
AC A0A0G1UYP1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00018569, ECO:0000256|RuleBase:RU366046};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189, ECO:0000256|RuleBase:RU366046};
GN ORFNames=UX95_C0003G0004 {ECO:0000313|EMBL:KKU71133.1};
OS Candidatus Woesebacteria bacterium GW2011_GWD1_47_21.
OC Bacteria; Candidatus Woesebacteria.
OX NCBI_TaxID=1618594 {ECO:0000313|EMBL:KKU71133.1, ECO:0000313|Proteomes:UP000034575};
RN [1] {ECO:0000313|EMBL:KKU71133.1, ECO:0000313|Proteomes:UP000034575}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083,
CC ECO:0000256|RuleBase:RU366046};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911,
CC ECO:0000256|RuleBase:RU366046};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947, ECO:0000256|RuleBase:RU366046}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU366046}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637, ECO:0000256|RuleBase:RU366046}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKU71133.1}.
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DR EMBL; LCOD01000003; KKU71133.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1UYP1; -.
DR PATRIC; fig|1618594.3.peg.73; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000034575; Unassembled WGS sequence.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR NCBIfam; TIGR01179; galE; 1.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|RuleBase:RU366046};
KW Galactose metabolism {ECO:0000256|ARBA:ARBA00023144};
KW Isomerase {ECO:0000256|RuleBase:RU366046};
KW NAD {ECO:0000256|RuleBase:RU366046}.
FT DOMAIN 5..253
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 329 AA; 35891 MW; 5209F13C903193C8 CRC64;
MNGKILVTGG AGYIGSFIVR KLKEAGFDVL IVDSLIHGHP EAVPGFELVK IDLVTEKDKL
DELLGKEKFA GVIHMAAFIQ MGESYEKPGM YFRNNVVGSL NLLETMAKHG VSNFVFSSSA
GVYGEPENIP IKEDDPKDPA NPYGETKLIV ERMLPWFDQA HGLKFISIRY FNAAGAALDG
SIGADQPNES HIIPRALVAV LKGEKFTLFG GDYQTVDGTC VRDYVHVLDL AEAHVLALKA
LMGGAESNFY NAGYGQGYSN KQIVGMIKKV TGLDLKVEIG PRRPGDTAAL VASIDKIKAD
FGWEPKYGLK EIIESAYLWH KNHPDGYKG
//
