ID A0A0G1WAJ9_9BACT Unreviewed; 649 AA.
AC A0A0G1WAJ9;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=UY54_C0003G0007 {ECO:0000313|EMBL:KKW15831.1};
OS Parcubacteria group bacterium GW2011_GWA2_50_10b.
OC Bacteria.
OX NCBI_TaxID=1618854 {ECO:0000313|EMBL:KKW15831.1, ECO:0000313|Proteomes:UP000034043};
RN [1] {ECO:0000313|EMBL:KKW15831.1, ECO:0000313|Proteomes:UP000034043}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKW15831.1}.
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DR EMBL; LCQJ01000003; KKW15831.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1WAJ9; -.
DR PATRIC; fig|1618854.3.peg.56; -.
DR Proteomes; UP000034043; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 4..292
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 293..549
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 25..32
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 649 AA; 73428 MW; C02232D75B585874 CRC64;
MTSERLNSEQ KRAVLAVDGP VLILAGAGAG KTKTIAERIR HLVRSGVSPS SILAITFTNK
ASREMRERVE RGLSEDPAIN RPVSMAERPF VSTFHALGVH ILREQSLKAG IKRHFAIFDR
DDSKRAVKEA LVTLGFDPKT HEPGAVLSVI SKLKGRGINV EEWSEAEQGG YFLDVVAQVW
PEYERALKRE DALDFDDLLL KTSNLLREDP AVRGYYQSVW RYIHIDEYQD TNRVQYDISK
MLVGVGENIC VVGDIDQNIY SWRGADIKNI LDFEKDYPKA QVITLEENYR STKTILEAAN
AVIEKNKIRR KKNLFTSNAA GEKITAIGLI DEATEAAFIA SKAREFIKNG IPPDEMAVLY
RANFQSRVLE EAFMSAEVPY QILGTRFFER KEVKDIISYL RAAKNPESLS DLKRIINTPA
RGIGKTTILK IFGGTAESLP LAMKTKIAVF RKLLSKIAEI SAEKRVSETI SFIIKESGLE
EEWKEGGEDG AARLENTYEL VNFASRYDAM PPEEGILSFL SETALQSDQD ELKEERKAVR
LMTVHAAKGL EFDVVFISGL EDGLFPHQRM NQSNITAEEA EEERRLFYVA LTRARKKIFL
SYAQVRTVFG RQQVNMPSEF IFDIPENLVE QEIIEESMGR RRPLLEIEF
//
