ID A0A0G1WFD9_9BACT Unreviewed; 534 AA.
AC A0A0G1WFD9;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=UY57_C0016G0017 {ECO:0000313|EMBL:KKW17511.1};
OS Candidatus Kaiserbacteria bacterium GW2011_GWB1_50_17.
OC Bacteria; Candidatus Kaiserbacteria.
OX NCBI_TaxID=1618673 {ECO:0000313|EMBL:KKW17511.1, ECO:0000313|Proteomes:UP000034120};
RN [1] {ECO:0000313|EMBL:KKW17511.1, ECO:0000313|Proteomes:UP000034120}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKW17511.1}.
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DR EMBL; LCQM01000016; KKW17511.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1WFD9; -.
DR PATRIC; fig|1618673.3.peg.259; -.
DR Proteomes; UP000034120; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 74..243
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 335..519
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 534 AA; 59676 MW; 48D61704D51E7630 CRC64;
MGWYRKLFRR LFSWFEVVAI VGIAIALFVF GVGVIWATLS PLPAIENFES RRVAESTKIY
DRTGNIILYD VHGSMRRTEV PIENISRYIR NATVAIEDDT FYQHNGFRPL SFIRAVLVNL
HLRGGIAGQG GSTITQQVVK NALLTKDKTI VRKAKEIILA LRLERIYTKD EILQTYLNEA
PYGGTLYGAE EASRYFFGVS AADVTLAQSA YLAALPQAPT RYSPYGTRRS ELDDRKNLVL
RRMYELGYIR EEEYRAARDE TVVFQSREET GIKAAHFVFY VREYLEDTYG PDVVTNGGLQ
VITTLDYDLQ KKAEEIVRER ALENKTKFNA ENAGLVAIDP KTGQILAMVG SRGFFDPDID
GMVNVTVMPR QPGSAFKPFV YATAFEKGYT PETVVFDLKT QFTAHCAPND LETHDDCYAP
GNYDNVFRGP MTLRDALAQS VNVPAVKTLY LAGVEASIGL ARRVGITTLA DAGRYGLTLV
LGGGEVYLLD MTAAYATFAN DGIKNPPVAI LRITDDVKKT LEEYKAKSER VLLL
//
