ID A0A0G1WGC2_9BACT Unreviewed; 495 AA.
AC A0A0G1WGC2;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Replicative DNA helicase {ECO:0000256|ARBA:ARBA00021957, ECO:0000256|RuleBase:RU362085};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU362085};
DE Flags: Fragment;
GN ORFNames=UY60_C0030G0006 {ECO:0000313|EMBL:KKW17848.1};
OS Parcubacteria group bacterium GW2011_GWB1_50_9.
OC Bacteria.
OX NCBI_TaxID=1618884 {ECO:0000313|EMBL:KKW17848.1, ECO:0000313|Proteomes:UP000034442};
RN [1] {ECO:0000313|EMBL:KKW17848.1, ECO:0000313|Proteomes:UP000034442}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- FUNCTION: Participates in initiation and elongation during chromosome
CC replication; it exhibits DNA-dependent ATPase activity.
CC {ECO:0000256|ARBA:ARBA00002835, ECO:0000256|RuleBase:RU362085}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665,
CC ECO:0000256|RuleBase:RU362085};
CC -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
CC {ECO:0000256|ARBA:ARBA00008428, ECO:0000256|RuleBase:RU362085}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKW17848.1}.
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DR EMBL; LCQP01000030; KKW17848.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1WGC2; -.
DR PATRIC; fig|1618884.3.peg.569; -.
DR Proteomes; UP000034442; Unassembled WGS sequence.
DR GO; GO:1990077; C:primosome complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-UniRule.
DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR CDD; cd00984; DnaB_C; 1.
DR CDD; cd00081; Hint; 1.
DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR InterPro; IPR007692; DNA_helicase_DnaB.
DR InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR InterPro; IPR016136; DNA_helicase_N/primase_C.
DR InterPro; IPR003587; Hint_dom_N.
DR InterPro; IPR036844; Hint_dom_sf.
DR InterPro; IPR006141; Intein_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR00665; DnaB; 1.
DR NCBIfam; TIGR01445; intein_Nterm; 1.
DR PANTHER; PTHR30153:SF2; REPLICATIVE DNA HELICASE; 1.
DR PANTHER; PTHR30153; REPLICATIVE DNA HELICASE DNAB; 1.
DR Pfam; PF00772; DnaB; 1.
DR Pfam; PF03796; DnaB_C; 1.
DR Pfam; PF14890; Intein_splicing; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00306; HintN; 1.
DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1.
DR SUPFAM; SSF48024; N-terminal domain of DnaB helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50817; INTEIN_N_TER; 1.
DR PROSITE; PS51199; SF4_HELICASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362085};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU362085};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU362085};
KW Helicase {ECO:0000256|RuleBase:RU362085, ECO:0000313|EMBL:KKW17848.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362085};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362085};
KW Primosome {ECO:0000256|ARBA:ARBA00022515, ECO:0000256|RuleBase:RU362085};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 178..383
FT /note="SF4 helicase"
FT /evidence="ECO:0000259|PROSITE:PS51199"
FT NON_TER 495
FT /evidence="ECO:0000313|EMBL:KKW17848.1"
SQ SEQUENCE 495 AA; 54408 MW; 15992CC918011BA3 CRC64;
MAEKALRVPP QDTEMERALL GALLLNQNAM YEVADLVGVD SFYSGKHRIV FDAMLSLYAK
SEPIDVVTVS GKLKERKQLT EIGGAAFLGE LTGAAASPGS AKHYAESVQT KFVLRALLDA
AAKIGELGFQ EDREIEEILD EAQAAVFSVT QTPMLRSFSS IKDELTEAWE RLERLQKHEG
TLRGVPTGFP QLDNMLAGLQ KSDLILLAAR PSMGKTALAL DIARLSATKH GTSTAVFSLE
MSSQQLVDRM LAAQSGVNAW RLRTGKIKSE EEFERLQEGM SVLAEAPIYI DDKASSTVLQ
MRSVARRLKM EKGLGLVIVD YLQLITPTHT KGGDSMVQVT EISRALKGMA RELDIPVLAL
SQLSRAVEQR RGRPRLSDLR DSGCLAGDTL LTRADTGERV AIKDLVGQEN IPIHSLTADY
RIMPLVISRV FSSGQKQLYE LRVRSGRTIK ASGNHPFLTF RGWDRLDTLK PGDRIALPRM
LSVAQTADAY SKDEI
//
