ID A0A0G1WU78_9BACT Unreviewed; 1065 AA.
AC A0A0G1WU78;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 13-SEP-2023, entry version 27.
DE RecName: Full=DNA polymerase III subunit alpha {ECO:0000256|ARBA:ARBA00019114};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=UY14_C0015G0005 {ECO:0000313|EMBL:KKU85710.1};
OS Parcubacteria group bacterium GW2011_GWA1_47_9.
OC Bacteria.
OX NCBI_TaxID=1618794 {ECO:0000313|EMBL:KKU85710.1, ECO:0000313|Proteomes:UP000034041};
RN [1] {ECO:0000313|EMBL:KKU85710.1, ECO:0000313|Proteomes:UP000034041}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKU85710.1}.
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DR EMBL; LCOW01000015; KKU85710.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1WU78; -.
DR PATRIC; fig|1618794.3.peg.311; -.
DR Proteomes; UP000034041; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd04485; DnaE_OBF; 1.
DR CDD; cd12113; PHP_PolIIIA_DnaE3; 1.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 1.10.10.1600; Bacterial DNA polymerase III alpha subunit, thumb domain; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR041931; DNA_pol3_alpha_thumb_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004365; NA-bd_OB_tRNA.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR InterPro; IPR016195; Pol/histidinol_Pase-like.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR PANTHER; PTHR32294:SF0; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR Pfam; PF01336; tRNA_anti-codon; 1.
DR SMART; SM00481; POLIIIAc; 1.
DR SUPFAM; SSF89550; PHP domain-like; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..72
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
SQ SEQUENCE 1065 AA; 119700 MW; 3EE14D36A8B6622A CRC64;
MTNFIHLHTH SHYSLLDGLS KIDDMVKLAK ELEMPAIGIT DHGAMYGVID FYTACVKNGI
KPVIGVEVYI ANRSRLQKEP HIDNKRYHLT LLAKDNAGYQ NLIKLTTAAH LEGYYYKPRI
DKELLRARSE GLIALSGCPA GELGRAIKSG NMEKAEAVIR EYQEIFGPEN YYLEIMHHPD
VEFFQEWRSA LIELSRKLNI PLVATQDSHY LRPDDAVAHK TLVAISTNTD IGDTAIFSGK
GEYHFISTEE ALERFKDIPE AVENTAKIAE RCNVNLTLGK FIFPDFALEP GKTADQMLDE
LTLNGARGRG LDQDPEVEKR RQYELEVIKN KNYSPYFLVV ADLLRFARES KIYTTVRGSG
AGSLVAYLSG ITNVNPIEFQ LPFERFLNPF RPSAPDFDMD FADNRRQEVI EYAKRKYGAD
KVAQIGTFGT MMARGAVRDV ARATGKPYET GDRIAKLIPM GSQGFPMSID RAMELEPELK
NIYERDSEAR QILDIAKKLE GTVRHVSVHA AGVVIAPKPL VEYVPTQFDP KSETNIITQY
DMYTVGEDGI GLTKLDFLGI RNLAILENAV HLVKQHRNTD IDIEKIPFDD KKTFAMLAKG
ETEGLFQLNG EGMTKHLKEL KPTTIHDINA MVALYRPGPI NNISEYIARK QGRSPIKYFH
PKAENFLAKS YGILVYQDDL LFTAMELAGY NWETVDKFRK AVGKKIPVEM AKQHKIFVEG
CQTHSGMSEK QAEQVWNLFE PFQGYGFNKA HAACYGRVAY QTAHMKANYS TEYMCAVLTA
EAGDTEKIAE IITECQRMGI PVLPPDINSS FKDFTVIKNQ QSADQIRFGL LTIKNLGEGV
ADAVIAERNT VGPYKNLEDF IFRSQSKILN KKSLEALIKC GALDAFGERN MLLFNLENIL
TCVRDKEKEI NSGQTNLFGD AGPALPPLHL VPTNPVQIWE KLMWEKELLG LFVSDHPLNS
YQQELKLQNV VQIKDAVSRN GSSVKIGGII TKTQKIITKT GRPMIFSWVE DLTSKIEVVV
FPNVLEKNPE AWKENSIIVA RGKINDRDGA LKLLCDDVKT LASMA
//
