ID A0A0G1XCL2_9BACT Unreviewed; 856 AA.
AC A0A0G1XCL2;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=UY71_C0005G0012 {ECO:0000313|EMBL:KKW29043.1};
OS Parcubacteria group bacterium GW2011_GWB1_52_7.
OC Bacteria.
OX NCBI_TaxID=1618885 {ECO:0000313|EMBL:KKW29043.1, ECO:0000313|Proteomes:UP000034383};
RN [1] {ECO:0000313|EMBL:KKW29043.1, ECO:0000313|Proteomes:UP000034383}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKW29043.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LCRC01000005; KKW29043.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1XCL2; -.
DR PATRIC; fig|1618885.3.peg.215; -.
DR Proteomes; UP000034383; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 69..246
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 337..640
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 856 AA; 94433 MW; 88C6AB62978063AB CRC64;
MKIVGFLFKR SSLRRRIFFF ALYAGVAGVG VLGVLLFFVL RDLPDPARLT ERSLAQSTKI
YDRTGTTILY DVHGDEKRTI IPFEKLPAYL KQATIAIEDA DFYSHRGIDF KGILRALYID
LSMRDIRQGG STITQQLVTN SLLTRGRSAS EKIVRKIREV VLAIIIDSRY SKDEILALYL
NQIPYGSQAY GAEAAAETFF GKSAENLTLA ESAFLAALPR APSYYSPYGL HREELFGRKD
LVIERMEKLG FIASEEASRA KKEVLALRKQ KQNILAPAFV FYVRDYLREA YGEALVEQGG
LKVITTLDWE LQQKAEKVVR EGAERNSGLI KAKNAALAAM DPKTGEILAM VGSRDYFADP
EPRGCAPGLN CQFDPNVNVA LRPRQPGSAF KPFVYSTAFL KGYTPDTMLF DVPTEFNTNC
SPDGSAPSWV DPESCYSPGN YDETFRGPVT ARRSLAQSLN VPSVELLYLA GVEDSIKTAE
RLGITTVKPD PSRYGLALVL GGAEVTLLDM THAYGAFARD GVQTEKSAIL RIEDANGKIL
EEKKEEGFQA LDAEVARTIN DILSDNEARQ PIFSPNSSLH MPNRPVAAKT GTTQDYRDAW
TIGYTPSLVA GVWVGNNDNS PIQQKGSGVL AAAPIWRAFM DAALEKTPPE QFIKPLPVSV
EKPILKGFWQ GGRVVVIDKV SGKLATNETP EEFRWEIVTG EPHTILYWVD RDDPRGPAPE
NPADDPQFKN WEAALGAWLA THPVGPQPVV PTEYDTVHTE ANRPKLFVAA PLPGDVVKNG
EPVVVRLSFQ TAFRAKELDV IWDDEVRKTL LSPASPLELF FAIKNGDGSG EAILKVRLVD
EVGNKSEVAI PLLVTP
//
