ID A0A0G1XPZ3_9BACT Unreviewed; 646 AA.
AC A0A0G1XPZ3;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN ORFNames=UY77_C0009G0013 {ECO:0000313|EMBL:KKW32945.1};
OS Candidatus Uhrbacteria bacterium GW2011_GWA2_53_10.
OC Bacteria; Candidatus Uhrbacteria.
OX NCBI_TaxID=1618980 {ECO:0000313|EMBL:KKW32945.1, ECO:0000313|Proteomes:UP000034711};
RN [1] {ECO:0000313|EMBL:KKW32945.1, ECO:0000313|Proteomes:UP000034711}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC ChEBI:CHEBI:78435; EC=2.4.1.129;
CC Evidence={ECO:0000256|ARBA:ARBA00023988};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKW32945.1}.
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DR EMBL; LCRI01000009; KKW32945.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1XPZ3; -.
DR PATRIC; fig|1618980.3.peg.206; -.
DR Proteomes; UP000034711; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001264; Glyco_trans_51.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR InterPro; IPR036950; PBP_transglycosylase.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR32282:SF33; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; 1.
DR Pfam; PF00912; Transgly; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF53955; Lysozyme-like; 1.
PE 4: Predicted;
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 116..269
FT /note="Glycosyl transferase family 51"
FT /evidence="ECO:0000259|Pfam:PF00912"
FT DOMAIN 359..635
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
SQ SEQUENCE 646 AA; 71032 MW; 830D30F41405A5A9 CRC64;
MASLSSHRGY TWRRSRSSSE HRKGSGRFNK EWAKNAVLLG IAALFAGSIG ILGVFAYVSR
DLPDPNALTE RLVKQSTKIY DRTGEHLLYE IYSDENRTLV KMQEGFCKDK PLEETDHAGI
PLLAIQATIA AEDRVFCAHH GFTVKGLARA VLFGGSRGGG STLTQQLVKN AVLSNEKTLT
RKAKELILSI ELERRYSKDE ILQIYFNEIP YGSTYYGIQA AAQNYFRKTV NGLSLAEVAT
LAALPKSPTT YLNNPDLLHA RRDWILNEMV EMGFVTAEAA SEAKAQETPV KVKVTNIQAP
HFVFYVKEAL EERYGRRTVE EGGLKVLTSL NFNLQTAAEE AVTSGVDTRG KQYQFTNASL
VAMDPKTGQV LAMVGSKDYF DDDIDGQVNV SLRPRQPGSS FKPIVYAKAF ASSYTPNTIL
WDVKTDFPTP VGIYAPNNYD LKERGPVRAR EALQGSLNIP AVEMLYLVGI DPTLNFAESL
GYTTFGNRSN FGLAIVLGGG EVKLLEHVNA YATFANAGVH FDPINILKVE DASGHILEEW
KAMDGRKVVE PNAAAMISNV LSDNSARSYV FGPTSYLQLG ARPVAAKTGT TNDYHDAWTV
GYTPSLAAGV WVGNNNYDAM KRGADGSIIA APIWNQRHRI HPCHLP
//
