ID A0A0G1XZN3_9BACT Unreviewed; 391 AA.
AC A0A0G1XZN3;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 08-NOV-2023, entry version 36.
DE RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
DE Flags: Fragment;
GN ORFNames=UY81_C0020G0001 {ECO:0000313|EMBL:KKW36618.1};
OS Candidatus Giovannonibacteria bacterium GW2011_GWA2_53_7.
OC Bacteria; Candidatus Giovannonibacteria.
OX NCBI_TaxID=1618650 {ECO:0000313|EMBL:KKW36618.1, ECO:0000313|Proteomes:UP000034290};
RN [1] {ECO:0000313|EMBL:KKW36618.1, ECO:0000313|Proteomes:UP000034290}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- FUNCTION: Plays an important role in the initiation and regulation of
CC chromosomal replication. Binds to the origin of replication; it binds
CC specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-
CC TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.
CC {ECO:0000256|RuleBase:RU000577}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|ARBA:ARBA00006583,
CC ECO:0000256|RuleBase:RU004227}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKW36618.1}.
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DR EMBL; LCRM01000020; KKW36618.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1XZN3; -.
DR PATRIC; fig|1618650.3.peg.250; -.
DR Proteomes; UP000034290; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd06571; Bac_DnaA_C; 1.
DR Gene3D; 1.10.1750.10; -; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00377; DnaA_bact; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR001957; Chromosome_initiator_DnaA.
DR InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR InterPro; IPR013317; DnaA.
DR InterPro; IPR013159; DnaA_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010921; Trp_repressor/repl_initiator.
DR NCBIfam; TIGR00362; DnaA; 1.
DR PANTHER; PTHR30050; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR PANTHER; PTHR30050:SF2; CHROMOSOMAL REPLICATION INITIATOR PROTEIN DNAA; 1.
DR Pfam; PF00308; Bac_DnaA; 1.
DR Pfam; PF08299; Bac_DnaA_C; 1.
DR PRINTS; PR00051; DNAA.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00760; Bac_DnaA_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48295; TrpR-like; 1.
DR PROSITE; PS01008; DNAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000577};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU000577};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000577};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000577}.
FT DOMAIN 89..221
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 299..368
FT /note="Chromosomal replication initiator DnaA C-terminal"
FT /evidence="ECO:0000259|SMART:SM00760"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KKW36618.1"
SQ SEQUENCE 391 AA; 44732 MW; 0E2B87741D18A786 CRC64;
KLILKALRTL DNSVRAVEYT VHRAPVATAE RKAPRREQTE NTAFDLGSLY VDKRDNLNPR
YTFDTFVVGP FNQLAHAAAK ALIERPGLAY NPLFIYGATG RGKTHLIQAI GNHFKKNRGN
VKVLYVTSER FAVDYINAVR SGRANNFKDQ YRQYDVLIMD DIQFIANTEK TQEELFHLFN
ALHDNNKQIV FSSDKHPMLL PGFEDRLKGR FQAGMIAEIP EPDVESRTAI IKAKIDQHGF
SLPDDIIQYI AENVRGNIRE LEGILNMIVC KSQLKGRVIS QADVRALIKH NIKPSRGVSV
DEVVRRIAGY YEIAEKSIYE KTRKKEVVRP RQIIMYMLRE EFNVSYPSIG EKLGGRDHTT
VIHSCEKIKE EVKTNNTLEQ EIEQIRALIH A
//
