ID A0A0G1YME1_9BACT Unreviewed; 797 AA.
AC A0A0G1YME1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Polymerase protein {ECO:0000313|EMBL:KKW07534.1};
GN ORFNames=UY42_C0011G0013 {ECO:0000313|EMBL:KKW07534.1};
OS Parcubacteria group bacterium GW2011_GWA2_49_16.
OC Bacteria.
OX NCBI_TaxID=1618851 {ECO:0000313|EMBL:KKW07534.1, ECO:0000313|Proteomes:UP000034608};
RN [1] {ECO:0000313|EMBL:KKW07534.1, ECO:0000313|Proteomes:UP000034608}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKW07534.1}.
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DR EMBL; LCPY01000011; KKW07534.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1YME1; -.
DR PATRIC; fig|1618851.3.peg.369; -.
DR Proteomes; UP000034608; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd08637; DNA_pol_A_pol_I_C; 1.
DR CDD; cd09898; H3TH_53EXO; 1.
DR CDD; cd09859; PIN_53EXO; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR InterPro; IPR002421; 5-3_exonuclease.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR020045; DNA_polI_H3TH.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF01367; 5_3_exonuc; 1.
DR Pfam; PF02739; 5_3_exonuc_N; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00475; 53EXOc; 1.
DR SMART; SM00279; HhH2; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..277
FT /note="5'-3' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00475"
FT DOMAIN 541..749
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 797 AA; 89174 MW; 9B9ED5CFFC913B7C CRC64;
MKKKDSQKTL ILLDAHAILH RAYHALPGFT SSTGEPTGAT YGLSTMLMKI IKDLKPDYIA
GCFDLPQPTF RHEAYEAYKQ GRAKTEDDLV HQIKRARDVF AALAIPSYEL PGFEADDLLA
TIVEKMKDKK DLRIIIASGD MDTLQLVDDD RVLVYTLKKG INDTILYDEK AVVERFGFVP
KLLPDYKGLR GDPSDNIIGI KGIGEKTATT LITMFGSVEN MYKKLKKDPE KFRAAGVSPR
IITLLEEGEE EALFSKTLAT VRRDAPIEFS LPEKEWRENF DLARAETLFA ELEFRALRGR
LNELNGGANK ATLFPEEEKN ESVIDPTEFK HAQLALWLLN SDLTTPSLED MLHYTKKKNF
VDAFVALEAE IGKQGLGSVY RDIELPLIPI IEEAQTYGIL VDTKHLKKLS ETYHKTLDEI
TTRIYTHAGG EFNMNSPKQL GEVLFDKMGL ATKGLKKTEG GARSTRESEL VKLREVHPII
AEILLYRELQ KLLSTYIDNL PQLTLEDGRL HTTLNQAGTT TGRMSSSNPN LQNIPVRGEM
GAAIRSAFVA PEGSTLLACD YSQIEMRVLA ALSGDENLFE IFKTGADVHT SVASRVFHVS
PQDVTAEMRR RAKVINFGIV YGMGVNALKD NLGSTRVEAQ EFYNNYFVTF PKIARYFEDV
KSRAKKDGFT TTYFGRRRFF AGLKSPIPYI RASAERMAMN APLQGTAADI IKIAMKRAHD
GLAGAKLLDK AHLLLQIHDE LLYEVEEGVV KKARTIIEDA MEHAVDFPVP ITVSVKEGPR
WGSMEGVERN GIENVEL
//
