ID A0A0G1YZC1_9BACT Unreviewed; 513 AA.
AC A0A0G1YZC1;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00018753};
DE EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
DE AltName: Full=Methionyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030904};
GN Name=metS {ECO:0000313|EMBL:KKW20357.1};
GN ORFNames=UY61_C0036G0004 {ECO:0000313|EMBL:KKW20357.1};
OS Candidatus Adlerbacteria bacterium GW2011_GWC1_50_9.
OC Bacteria; Candidatus Adlerbacteria.
OX NCBI_TaxID=1618608 {ECO:0000313|EMBL:KKW20357.1, ECO:0000313|Proteomes:UP000034201};
RN [1] {ECO:0000313|EMBL:KKW20357.1, ECO:0000313|Proteomes:UP000034201}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Brown C.T., Hug L.A., Thomas B.C., Sharon I., Castelle C.J., Singh A.,
RA Wilkins M.J., Williams K.H., Banfield J.F.;
RT "rRNA introns, odd ribosomes, and small enigmatic genomes across a large
RT radiation of phyla.";
RL Nature 0:0-0(2015).
CC -!- FUNCTION: Is required not only for elongation of protein synthesis but
CC also for the initiation of all mRNA translation through initiator
CC tRNA(fMet) aminoacylation. {ECO:0000256|ARBA:ARBA00003314}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|RuleBase:RU363039}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKW20357.1}.
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DR EMBL; LCQQ01000036; KKW20357.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G1YZC1; -.
DR PATRIC; fig|1618608.3.peg.545; -.
DR Proteomes; UP000034201; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd00814; MetRS_core; 1.
DR Gene3D; 2.170.220.10; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR041872; Anticodon_Met.
DR InterPro; IPR014758; Met-tRNA_synth.
DR InterPro; IPR023457; Met-tRNA_synth_2.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR033911; MetRS_core.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR032678; tRNA-synt_1_cat_dom.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00398; metG; 1.
DR PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR Pfam; PF19303; Anticodon_3; 1.
DR Pfam; PF01406; tRNA-synt_1e; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR PRINTS; PR01041; TRNASYNTHMET.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363039};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363039};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363039}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 18..138
FT /note="tRNA synthetases class I catalytic"
FT /evidence="ECO:0000259|Pfam:PF01406"
FT DOMAIN 142..364
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
FT DOMAIN 410..491
FT /note="Methionyl-tRNA synthetase anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF19303"
SQ SEQUENCE 513 AA; 58955 MW; B85E80FA15107B05 CRC64;
MKNRMQKKFY LTTAIDYVNG APHIGHAVQK VWADIIARYH RLLGEKVWFL TGTDEHGANV
VRTAASAGKS PKELADENSA KFRNFKEALN LSWDDFIRTS DEARHWPGVQ EFWKRLTEAG
DIYKSDYRGL YCLGHEAFIT EKDLVDGKCK LHGREPEAIN EENYFFRLSK YSGEIKERIR
SGELQILPES RKNEILSLLE EGLEDVSFSR PSKDISWGVP VPGDATQTVY VWAEALINYL
SAVGYGRNDD WQGWWPADLH VFGKDNLRFH AAIWPGMLMS AKLSLPRMLL CHGFIQVGGR
KMSKTLGNVV DPFEIVKNFG TDALRYYFSR EITIFEDGDF TEERFGETYE ANLVNGLGNY
VRRVATMIKN DFGGQLERPA QEKIDSVPLQ KGELEYVSVP YFTDHVAWPE YHRAMENFEI
NRAADITFNL IKELDGYVQR YEPFKLVKTD QEKARAVLWN LAYGAVSLAW MLSPFLPETS
GKILDIFGAE GERESEWKRF VVKDRPPLFP RIP
//
