GenomeNet

Database: UniProt
Entry: A0A0G2HPM9_9PEZI
LinkDB: A0A0G2HPM9_9PEZI
Original site: A0A0G2HPM9_9PEZI 
ID   A0A0G2HPM9_9PEZI        Unreviewed;       360 AA.
AC   A0A0G2HPM9;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   08-NOV-2023, entry version 18.
DE   RecName: Full=Porphobilinogen deaminase {ECO:0000256|ARBA:ARBA00016519};
DE            EC=2.5.1.61 {ECO:0000256|ARBA:ARBA00012655};
DE   AltName: Full=Hydroxymethylbilane synthase {ECO:0000256|ARBA:ARBA00033064};
DE   AltName: Full=Pre-uroporphyrinogen synthase {ECO:0000256|ARBA:ARBA00030685};
GN   ORFNames=UCDDA912_g09905 {ECO:0000313|EMBL:KKY30180.1};
OS   Diaporthe ampelina.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Diaporthales; Diaporthaceae; Diaporthe.
OX   NCBI_TaxID=1214573 {ECO:0000313|EMBL:KKY30180.1, ECO:0000313|Proteomes:UP000034680};
RN   [1] {ECO:0000313|EMBL:KKY30180.1, ECO:0000313|Proteomes:UP000034680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DA912 {ECO:0000313|EMBL:KKY30180.1};
RA   Lawrence D.P., Travadon R., Rolshausen P.E., Baumgartner K.;
RT   "Distinctive expansion of gene families associated with plant cell wall
RT   degradation and secondary metabolism in the genomes of grapevine trunk
RT   pathogens.";
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:KKY30180.1, ECO:0000313|Proteomes:UP000034680}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DA912 {ECO:0000313|EMBL:KKY30180.1};
RA   Morales-Cruz A., Amrine K.C., Cantu D.;
RL   Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=dipyrromethane; Xref=ChEBI:CHEBI:60342;
CC         Evidence={ECO:0000256|ARBA:ARBA00001916};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.
CC       {ECO:0000256|ARBA:ARBA00004735}.
CC   -!- SIMILARITY: Belongs to the HMBS family.
CC       {ECO:0000256|ARBA:ARBA00005638}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKY30180.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LCUC01000521; KKY30180.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G2HPM9; -.
DR   STRING; 1214573.A0A0G2HPM9; -.
DR   OrthoDB; 788at2759; -.
DR   UniPathway; UPA00251; UER00319.
DR   Proteomes; UP000034680; Unassembled WGS sequence.
DR   GO; GO:0004418; F:hydroxymethylbilane synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR   Gene3D; 3.30.160.40; Porphobilinogen deaminase, C-terminal domain; 1.
DR   InterPro; IPR000860; HemC.
DR   InterPro; IPR022419; Porphobilin_deaminase_cofac_BS.
DR   InterPro; IPR022417; Porphobilin_deaminase_N.
DR   InterPro; IPR022418; Porphobilinogen_deaminase_C.
DR   InterPro; IPR036803; Porphobilinogen_deaminase_C_sf.
DR   NCBIfam; TIGR00212; hemC; 1.
DR   PANTHER; PTHR11557; PORPHOBILINOGEN DEAMINASE; 1.
DR   PANTHER; PTHR11557:SF0; PORPHOBILINOGEN DEAMINASE; 1.
DR   Pfam; PF01379; Porphobil_deam; 1.
DR   Pfam; PF03900; Porphobil_deamC; 1.
DR   PIRSF; PIRSF001438; 4pyrrol_synth_OHMeBilane_synth; 1.
DR   PRINTS; PR00151; PORPHBDMNASE.
DR   SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR   SUPFAM; SSF54782; Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain; 1.
DR   PROSITE; PS00533; PORPHOBILINOGEN_DEAM; 1.
PE   3: Inferred from homology;
KW   Heme biosynthesis {ECO:0000256|ARBA:ARBA00023133};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034680};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          19..237
FT                   /note="Porphobilinogen deaminase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01379"
FT   DOMAIN          251..328
FT                   /note="Porphobilinogen deaminase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03900"
SQ   SEQUENCE   360 AA;  38175 MW;  036DAB0A1272D7DF CRC64;
     MAAVVDAPPP VPLPAGTTVR VGTRRSGLAL KQCEIVISEL SKTYPHINFE TVTVSVMGDR
     DKTTPLPNLG KGLWTSELEA MLTSSPPELD MIVHSLKDMP TSLPDGCVLG CVTRREDPRD
     VVVFRAAHGD RYRKLADLPQ GAVVGTSSVR RSAQLRRRYP GLVFKDVRGN IDTRLRKCDD
     DALGYDAIIL AAAGLLRMDC GHRIGQYLES ASEGGGMLHA VGQGALGIEV RSDDEATLGL
     LKGVLHTETM LACEAERTVM RTLEGGCSVP IGVETDWVPG ENGIGQVLRM RATVISLDGS
     QGAETEVTQE VSDAKAAEEL GHKVASILVE KGAGKILEAI NKTRAETPAA GTSATTAATT
//
DBGET integrated database retrieval system