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Database: UniProt
Entry: A0A0G2I5T0_9EURO
LinkDB: A0A0G2I5T0_9EURO
Original site: A0A0G2I5T0_9EURO 
ID   A0A0G2I5T0_9EURO        Unreviewed;       848 AA.
AC   A0A0G2I5T0;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   05-DEC-2018, entry version 10.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=EMCG_08266 {ECO:0000313|EMBL:KKZ65972.1};
OS   Emmonsia crescens UAMH 3008.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Emmonsia.
OX   NCBI_TaxID=1247875 {ECO:0000313|EMBL:KKZ65972.1, ECO:0000313|Proteomes:UP000034164};
RN   [1] {ECO:0000313|Proteomes:UP000034164}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 3008 {ECO:0000313|Proteomes:UP000034164};
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W.,
RA   McEwen J.G., Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-
CC         (deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP +
CC         diphosphate.; EC=6.5.1.1;
CC         Evidence={ECO:0000256|RuleBase:RU000617};
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KKZ65972.1}.
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DR   EMBL; LCZI01000550; KKZ65972.1; -; Genomic_DNA.
DR   EnsemblFungi; KKZ65972; KKZ65972; EMCG_08266.
DR   Proteomes; UP000034164; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000034164};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:KKZ65972.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034164}.
FT   DOMAIN      527    707       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
SQ   SEQUENCE   848 AA;  94690 MW;  67F4351FDE7D7FFA CRC64;
     MPSPAKKRKI NDAEPARQRI RGIKSFFESQ NATPTATTSA PAEPAILLTD EELARKLQAE
     WNEEAKSNHQ SPSAPKDSRV LISQEAKPED RDQQSGLEPQ PHTPSSADVP RNNTPKSVLS
     LQTSSNDEDT ISQSIPFDQS PLTFDPSAYI KQLRTHWAVE GGHASYAILT RAFVLVSNTQ
     SRIKIVDTLV NFLRIIIEAN PDSLVPAVWL ATNAIAPPYV PLELGLGGSA ISKALKSAYG
     LNNQGLKTLY DKHGDAGDVA FEAKKRQTFT LRKPRPLSIR GVYESLLKIS RSKGPGSQET
     KQRIVEKLLQ DTRGAEESRY IVRTLVQHLR IGAVKTTMLI ALARAFLFSR PATSNFSVYK
     DLLKLKKEEV ASIYNRAEEI VKACYARHPN YNDLVPCLLE IGISDELIVR CGLTLHIPLR
     PMLGSITRDL AQMLTKLQGR AFTCEYKYDG QRAQVHCDSS GTVSIFSRNL EIMTDKYPDL
     VALTPRIRSE GVSSFILEGE IVAVNRGTGE LLAFQTLTNR AKKNVGIDSI KISVCLFAFD
     LMFLNGEPLL ERPLRERREL LRGLFIEVPH HFTWVKSIDA TSSDSEAVLD FFKDATDAKC
     EGLMVKLLDD DTVQPELSKE ESVAEPISTS EPPSTPTTVK PNGNAKGRGR RFPLSTYEPD
     KRLESWLKVK KDYSAASDTL DLIPIAAWHG QGRKAKWWSP ILLAVRNPET GLLEAVTKCI
     SGFTDKFYQA NKEKYAEGSD NIISRPSYVE YRNEPEVWFE PQEVWEVAFA DITFSPTYTA
     AIGLVSDERG LSLRFPRFIR VREDKGIEEA SSSEYLASLW RKQTEQLQEE GALIKREAGN
     DNFGSEDE
//
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