ID A0A0G2I6M8_9EURO Unreviewed; 902 AA.
AC A0A0G2I6M8;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Peroxisomal hydratase-dehydrogenase-epimerase {ECO:0000313|EMBL:KKZ66287.1};
GN ORFNames=EMCG_07997 {ECO:0000313|EMBL:KKZ66287.1};
OS Emmonsia crescens UAMH 3008.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Emmonsia.
OX NCBI_TaxID=1247875 {ECO:0000313|EMBL:KKZ66287.1, ECO:0000313|Proteomes:UP000034164};
RN [1] {ECO:0000313|Proteomes:UP000034164}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 3008 {ECO:0000313|Proteomes:UP000034164};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKZ66287.1}.
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DR EMBL; LCZI01000500; KKZ66287.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G2I6M8; -.
DR VEuPathDB; FungiDB:EMCG_07997; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000034164; Unassembled WGS sequence.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd03448; HDE_HSD; 1.
DR CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 2.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR45024; DEHYDROGENASES, SHORT CHAIN; 1.
DR PANTHER; PTHR45024:SF2; SCP2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00106; adh_short; 2.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS00061; ADH_SHORT; 2.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT DOMAIN 779..889
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
SQ SEQUENCE 902 AA; 97169 MW; FFD5F061BC3699FC CRC64;
MSELRFDNQT VVVTGAGGGL GKAYAIFFGK RGANVVVNDL GVSHRGEGTS SKAADAVVDE
IKAAGGKAVA NYDSVEYGDR IIDTAIKAFG RVDILINNAG ILRDISFKNM KDLDWDLIDK
VHVYGSYKCA RAAWPYFRKQ KFGRVINTSS SAGLFGSFGQ TNYSAAKLAM VGFTETLAKE
GAKYNIMANV IAPIAASRMT ETVMPPDVLE HLKPDWIVPL VAVLVHSSNT SESGGIFEAG
AGHMAKLRWE RAKGALLKTD DTLTPQAILA KWNDVKDFSE PSYPTGAANF LELLERAQTV
PSAPTGENLD FTGKVALITG AGAGLGRAYA LLFAKLGASV VVNDLVDPEP VVQEIRKLGG
KAVGSKASVE DGEAVVKPAI DAFGRIDILV NNAGILRDKA FTNMDDNMWN TIMNVHLKGT
YKVTKAAWPY FLKQKYGRIV NTSSTSGIYG NFGQANYAAA KLGILGFSRA LALEGAKYNI
FVNTIAPNAG TALTRTVLPE ELVQAFKPEY VAPMVALLCS DKLPEPTKGL YECGSGWFAK
TRWQRTRGHG FHVDVQLTPE AVLSQWEKIV TFDEHSDHPE DGQAGVKSIM ANMSNVSGGK
KEEGSEGDQQ ILKAIETAKN MKAKGSPFDY ADKDVILYNI SLGAKRTDLQ FVYENSSDFQ
ALPTFGVVPW FTTATPWDVA DIVSNYSPMM LLHGEQYLEL RKFPIPTAAK TITIPTLIDV
VDKGNAALVV TGYTTKDART GEDLFYNEST MFIRGSGGFG GSPKPTARRA KAATAAYKPP
QRQPDAVMEE KTSDDQAALY RLNGDYNPLH IDPDFAKVGG FKAPILHGLC SFGIAGKHVF
KTFGAFKSIK VRFAGVVIPG QTLKTEMWKE NGVVAFQVTV VETGKLAIAG AGVELASTGS
KL
//