ID   A0A0G2IY95_9EURO        Unreviewed;       952 AA.
AC   A0A0G2IY95;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=PXA domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=EMCG_04867 {ECO:0000313|EMBL:KKZ60384.1};
OS   Emmonsia crescens UAMH 3008.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Emmonsia.
OX   NCBI_TaxID=1247875 {ECO:0000313|EMBL:KKZ60384.1, ECO:0000313|Proteomes:UP000034164};
RN   [1] {ECO:0000313|Proteomes:UP000034164}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UAMH 3008 {ECO:0000313|Proteomes:UP000034164};
RX   PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA   Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA   Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA   Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA   Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA   Clay O.K., Klein B.S., Cuomo C.A.;
RT   "The dynamic genome and transcriptome of the human fungal pathogen
RT   Blastomyces and close relative Emmonsia.";
RL   PLoS Genet. 11:E1005493-E1005493(2015).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KKZ60384.1}.
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DR   EMBL; LCZI01001537; KKZ60384.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0G2IY95; -.
DR   VEuPathDB; FungiDB:EMCG_04867; -.
DR   Proteomes; UP000034164; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   CDD; cd06093; PX_domain; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR013937; Sorting_nexin_C.
DR   PANTHER; PTHR22775:SF47; MEIOTICALLY UP-REGULATED GENE 122 PROTEIN; 1.
DR   PANTHER; PTHR22775; SORTING NEXIN; 1.
DR   Pfam; PF08628; Nexin_C; 1.
DR   Pfam; PF00787; PX; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          488..566
FT                   /note="PX"
FT                   /evidence="ECO:0000259|Pfam:PF00787"
FT   DOMAIN          816..932
FT                   /note="Sorting nexin C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08628"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          641..694
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          727..749
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          762..783
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          338..365
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        655..669
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   952 AA;  103542 MW;  F740E95E11766D5D CRC64;
     MEESQLKETT DASASIGDSI PPGPGDSAEC TVEATSTFHS MAVQSPLFDQ CLQFLSSANH
     ATLAALGGVI LAATYLFLGR LSLVLFGVFA GVGLHASWEG YKESGDESVK SDLSIRRREL
     GIEVANRLLS WDESRTADKS SKKTSLADIS TTELDYSDFQ PATAAALNTL TDAIIRDYVR
     PADIFLHFVT NASSIVVVFL NELSSALESA STTPISTADA IFSYLNEYPE SNLANVLSTS
     QQRAKLRLVA SDILQTFLEP GVILESIIDN CSKPEWINGW IVQLLEEGET ELMNVIDIGV
     DRARQDQLEA FATRSLADNS NIPEDSVNEE IAVENSRMNQ ENQGLTKAQI EMQEAVREAK
     RLSAMIAVDG RRNDEQPPTI GTDGDSDIGL DSISSKTSDL EATATWSDGN WNSNVTVRSE
     VSRSSNELGD VRNSINELRS KQGGSIQMIL LGASVSIFDD TIANDKGKMR VKPTDDYLLQ
     IEPASSRHPG WVIARKYYDF EVLHEVLRRI SVVSGVSGFI EQHKELPTWK GQYKSDLRQS
     LERYLQHALG FERLAGCEAM KRFLEKERGG ATSSPNGTGK GGFSFPSQAV FENMGKGVLE
     VLSNAPKGVA GGGKAVLEGV TGVFGAGSSI GKRSVDLVPR DRMDPKLRMS PSDFFNKPRI
     SQNARETEGT HSPSRSDTEY HIPPDYSSSE NGSEKSLAYV THNQEEDSAL KVPFAEQISR
     SIATEHIGEN QENGPIASEE HPHETKTVSS CLTGQATNAE GNRAIKSEPD IESPKSQFKP
     GSNGARVLSL SEEETGVAVE LLFAVINELY ALSSAWGIRK KLLNAAKSFL LRPGNPNIEA
     IRLLVQESLI ESNASDDALA THITVLRQNA LPTEDELKSW PPPLTDDEKK ELRIKARKLL
     VTRGMPQALT SIMGNAATAE ALGHVFDSLQ VKSVARGFIF ALMLQALKAV IQ
//