ID A0A0G2JA94_9EURO Unreviewed; 990 AA.
AC A0A0G2JA94;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=116 kDa U5 small nuclear ribonucleoprotein component {ECO:0000256|ARBA:ARBA00018774};
DE AltName: Full=U5 snRNP-specific protein, 116 kDa {ECO:0000256|ARBA:ARBA00031432};
GN ORFNames=EMCG_08852 {ECO:0000313|EMBL:KKZ65336.1};
OS Emmonsia crescens UAMH 3008.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Emmonsia.
OX NCBI_TaxID=1247875 {ECO:0000313|EMBL:KKZ65336.1, ECO:0000313|Proteomes:UP000034164};
RN [1] {ECO:0000313|Proteomes:UP000034164}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAMH 3008 {ECO:0000313|Proteomes:UP000034164};
RX PubMed=26439490; DOI=10.1371/journal.pgen.1005493;
RA Munoz J.F., Gauthier G.M., Desjardins C.A., Gallo J.E., Holder J.,
RA Sullivan T.D., Marty A.J., Carmen J.C., Chen Z., Ding L., Gujja S.,
RA Magrini V., Misas E., Mitreva M., Priest M., Saif S., Whiston E.A.,
RA Young S., Zeng Q., Goldman W.E., Mardis E.R., Taylor J.W., McEwen J.G.,
RA Clay O.K., Klein B.S., Cuomo C.A.;
RT "The dynamic genome and transcriptome of the human fungal pathogen
RT Blastomyces and close relative Emmonsia.";
RL PLoS Genet. 11:E1005493-E1005493(2015).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKZ65336.1}.
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DR EMBL; LCZI01000671; KKZ65336.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G2JA94; -.
DR VEuPathDB; FungiDB:EMCG_08852; -.
DR Proteomes; UP000034164; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd04098; eEF2_C_snRNP; 1.
DR CDD; cd04090; EF2_II_snRNP; 1.
DR CDD; cd01683; EF2_IV_snRNP; 1.
DR CDD; cd16264; snRNP_III; 1.
DR CDD; cd04167; Snu114p; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.90.1430.10; Yeast translation eEF2 (G' domain); 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031950; EFTUD2_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR044121; Snu114_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR InterPro; IPR035655; U5-116kDa_C.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF6; 116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF16004; EFTUD2; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:KKZ65336.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein biosynthesis {ECO:0000313|EMBL:KKZ65336.1};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 136..356
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 990 AA; 110960 MW; 8D1E1981C6D72B25 CRC64;
MDDLYDEFGN YIGEAEESEE ELRHGDARPD AYAYDLESEE DEEAGEGVAH DQQLMEVDEQ
GPSNAVILHE DKQYYPTAQQ VYGEGVETLV EEEDAQPLTQ PIIAPVQQKK FAVQEADLPP
VFYSREFMTD LLNFPDQTRN IALAGHLHHG KTAFMDTLVM QTHDLSERLD KRIGKRKDEQ
LRYTDVHFVE RERGLSMKSA PMSLVLQGTR GKSHLFNVID TPGHVNFVDE VAAAFRLVDG
VVLIVDVVEG VQINTEQIIK YAVLEDLPLT LVVNKMDRLI LELKLPPTDA YFKLKHVVEE
VNTIIERTLP GQGEKRRLSP EKGNVAFACS SMNWCFTLQS FAKMYADTYQ DIDIAEFGAR
LWGDIFFNPK SRKFTRKGVE ERSKRTFVHF VLEPIYKIIS HTISESPEDL KDTLATLGIH
LKPSQLKSDA RVLLKLVCEQ FFGPVDGFVD MVVQHIPSPK EGAPKKLEKY YTGPLDTKVA
ASMSTCNQDG PLVIQVTKLY STPDASRFNA FGRVMSGIAR PGQQVRVLGE GYTIDDEEDM
VIATISDTWI AETRYNIPTS GVPAGNWVLL SGVDNSIVKT ATLVPLKLED DEDAYIFKPI
KHMTESVFKV AVEPINPSEL PKMLEGLRKI NKSYPLISTK VEESGEHIVL GTGELYMDCV
LHDLRRLYAE MELKVSDPVT RFCETVVETS AIMCYAMTPN KKNKITMIAE PLDDGIAEDI
ESGRVIIRDP IRKVAQFFEQ KYDWDKLAAR SIWAFGPEEM GPNILQDDTL PSQVDKKLLG
TVRDSIRQGF SWGTREGPLC EEPIRNTKFK LTDISLADQA IFRGGGQIIP TARRAVYSSF
LMASPRLMEP IYTCSMTGPA DSVAAIYTVL SRRRGHVLSD GPIAGTPLYA VRGLIPVIDS
FGFETDLRIH TQGQATVSLV FDKWSVVPGD PLDRDVKLRP LDMASAMATA RDFVLKTRRR
KGLAEDVSVS KFLEPELWKG LRESGVLGEG
//
