ID A0A0G2JGK4_MOUSE Unreviewed; 133 AA.
AC A0A0G2JGK4;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Protein shisa-5 {ECO:0000256|ARBA:ARBA00040441};
DE AltName: Full=Scotin {ECO:0000256|ARBA:ARBA00041983};
GN Name=Shisa5 {ECO:0000313|Ensembl:ENSMUSP00000143599.2,
GN ECO:0000313|MGI:MGI:1915044};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000143599.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000143599.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000143599.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000143599.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000143599.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Can induce apoptosis in a caspase-dependent manner and plays
CC a role in p53/TP53-dependent apoptosis.
CC {ECO:0000256|ARBA:ARBA00037507}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the shisa family.
CC {ECO:0000256|ARBA:ARBA00038108}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_006512278.1; XM_006512215.2.
DR RefSeq; XP_006512279.1; XM_006512216.2.
DR RefSeq; XP_006512280.1; XM_006512217.1.
DR RefSeq; XP_006512281.1; XM_006512218.2.
DR RefSeq; XP_006512282.1; XM_006512219.2.
DR Antibodypedia; 30112; 176 antibodies from 18 providers.
DR Ensembl; ENSMUST00000196954.5; ENSMUSP00000143599.2; ENSMUSG00000025647.17.
DR Ensembl; ENSMUST00000197483.5; ENSMUSP00000143613.2; ENSMUSG00000025647.17.
DR Ensembl; ENSMUST00000198708.5; ENSMUSP00000142978.2; ENSMUSG00000025647.17.
DR AGR; MGI:1915044; -.
DR MGI; MGI:1915044; Shisa5.
DR VEuPathDB; HostDB:ENSMUSG00000025647; -.
DR GeneTree; ENSGT00390000008296; -.
DR BioGRID-ORCS; 66940; 3 hits in 75 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 9.
DR Bgee; ENSMUSG00000025647; Expressed in peripheral lymph node and 270 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31395:SF14; PROTEIN SHISA-5; 1.
DR PANTHER; PTHR31395; SHISA; 1.
DR Pfam; PF13908; Shisa; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 55..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..105
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 133 AA; 14292 MW; 6E5729CB5B8B408B CRC64;
MSGFGATVAI GVTIFVVFIA TIIICFTCSC CCLYKMCCPQ RPVVTNTTTT TVVHAPYPQP
QPQPVAPSYP GPTYQGYHPM PPQPGMPAAP YPTQYPPPYL AQPTGPPPYH ESLAGASQPP
YNPTYMDSLK TIP
//
