ID A0A0G2JMH6_HUMAN Unreviewed; 254 AA.
AC A0A0G2JMH6;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=HLA-DRA {ECO:0000313|EMBL:ARB08428.1};
DE SubName: Full=MHC class II antigen {ECO:0000313|EMBL:VUF79919.1};
GN Name=HLA-DRA {ECO:0000313|EMBL:ARB08428.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000479287, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000479287}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0007829|PubMed:24275569}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [4] {ECO:0000313|Ensembl:ENSP00000479287}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2015) to UniProtKB.
RN [5] {ECO:0000313|EMBL:ARB08428.1}
RP NUCLEOTIDE SEQUENCE.
RA Norman P.J., Norberg S.J., Guethlein L.A., Nemat-Gorgani N., Ronaghi M.,
RA Parham P.;
RT "HLA and other MHC gene sequence alleles derived from homozygous
RT individuals.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:VUF79919.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=? {ECO:0000313|EMBL:VUF79919.1};
RA Voorter E. C., Matern B.;
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004352}.
CC -!- SIMILARITY: Belongs to the MHC class II family.
CC {ECO:0000256|RuleBase:RU004238}.
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DR EMBL; AL662796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KY497338; ARB08428.1; -; Genomic_DNA.
DR EMBL; KY497339; ARB08429.1; -; Genomic_DNA.
DR EMBL; KY497342; ARB08432.1; -; Genomic_DNA.
DR EMBL; KY497344; ARB08434.1; -; Genomic_DNA.
DR EMBL; KY497345; ARB08435.1; -; Genomic_DNA.
DR EMBL; KY497347; ARB08437.1; -; Genomic_DNA.
DR EMBL; KY497353; ARB08443.1; -; Genomic_DNA.
DR EMBL; KY497355; ARB08445.1; -; Genomic_DNA.
DR EMBL; LR606122; VUF79919.1; -; Genomic_DNA.
DR EMBL; LR606123; VUF80073.1; -; Genomic_DNA.
DR EMBL; LR606124; VUF80074.1; -; Genomic_DNA.
DR EMBL; LR606126; VUF80076.1; -; Genomic_DNA.
DR EMBL; LR606127; VUF82240.1; -; Genomic_DNA.
DR EMBL; LR606128; VUF82727.1; -; Genomic_DNA.
DR EMBL; LR606129; VUF82728.1; -; Genomic_DNA.
DR EMBL; LR606130; VUF82729.1; -; Genomic_DNA.
DR EMBL; LR606132; VUF82731.1; -; Genomic_DNA.
DR EMBL; LR606277; VUG15781.1; -; Genomic_DNA.
DR EMBL; LR606278; VUG15782.1; -; Genomic_DNA.
DR EMBL; LR606281; VUG15785.1; -; Genomic_DNA.
DR EMBL; LR606282; VUG15787.1; -; Genomic_DNA.
DR RefSeq; NP_061984.2; NM_019111.4.
DR AlphaFoldDB; A0A0G2JMH6; -.
DR SMR; A0A0G2JMH6; -.
DR MassIVE; A0A0G2JMH6; -.
DR DNASU; 3122; -.
DR Ensembl; ENST00000613328; ENSP00000479287; ENSG00000277263.
DR GeneID; 3122; -.
DR KEGG; hsa:3122; -.
DR CTD; 3122; -.
DR OMA; QAEFYMT; -.
DR OrthoDB; 4118190at2759; -.
DR BioGRID-ORCS; 3122; 13 hits in 1142 CRISPR screens.
DR ChiTaRS; HLA-DRA; human.
DR GenomeRNAi; 3122; -.
DR Proteomes; UP000005640; Unplaced.
DR GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0042613; C:MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0023026; F:MHC class II protein complex binding; IBA:GO_Central.
DR GO; GO:0042605; F:peptide antigen binding; IBA:GO_Central.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IBA:GO_Central.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IBA:GO_Central.
DR GO; GO:0050778; P:positive regulation of immune response; IBA:GO_Central.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR CDD; cd21007; IgC1_MHC_II_alpha_HLA-DR; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR PANTHER; PTHR19944:SF86; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW MHC II {ECO:0000256|ARBA:ARBA00023182};
KW Proteomics identification {ECO:0007829|EPD:A0A0G2JMH6,
KW ECO:0007829|MaxQB:A0A0G2JMH6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..254
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014514161"
FT TRANSMEM 221..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 112..192
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 254 AA; 28621 MW; 3CD1CDBA89D92350 CRC64;
MAISGVPVLG FFIIAVLMSA QESWAIKEEH VIIQAEFYLN PDQSGEFMFD FDGDEIFHVD
MAKKETVWRL EEFGRFASFE AQGALANIAV DKANLEIMTK RSNYTPITNV PPEVTVLTNS
PVELREPNVL ICFIDKFTPP VVNVTWLRNG KPVTTGVSET VFLPREDHLF RKFHYLPFLP
STEDVYDCRV EHWGLDEPLL KHWEFDAPSP LPETTENVVC ALGLTVGLVG IIIGTIFIIK
GLRKSNAAER RGPL
//
