ID A0A0G2JRA5_HUMAN Unreviewed; 389 AA.
AC A0A0G2JRA5;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=RNA-binding protein fox-1 homolog 2 {ECO:0000313|Ensembl:ENSP00000486570.1};
DE Flags: Fragment;
GN Name=RBFOX2 {ECO:0000313|Ensembl:ENSP00000486570.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000486570.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000486570.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [2] {ECO:0007829|PubMed:24129315}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24129315;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [3] {ECO:0000313|Ensembl:ENSP00000486570.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AC239364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL049748; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL079295; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF457428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF510602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF510603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF511452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0G2JRA5; -.
DR SMR; A0A0G2JRA5; -.
DR MassIVE; A0A0G2JRA5; -.
DR PeptideAtlas; A0A0G2JRA5; -.
DR Ensembl; ENST00000625456.2; ENSP00000486570.1; ENSG00000277564.4.
DR HGNC; HGNC:9906; RBFOX2.
DR ChiTaRS; RBFOX2; human.
DR Proteomes; UP000005640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd12407; RRM_FOX1_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR025670; Fox-1_C_dom.
DR InterPro; IPR034237; FOX1_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR017325; RBFOX1-3.
DR InterPro; IPR047131; RBFOX1-like.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR15597; ATAXIN 2-BINDING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR15597:SF50; RNA BINDING PROTEIN FOX-1 HOMOLOG 2; 1.
DR Pfam; PF12414; Fox-1_C; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF037932; Ataxin_2_bd_A2BP; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW mRNA processing {ECO:0000256|ARBA:ARBA00023187};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Proteomics identification {ECO:0007829|EPD:A0A0G2JRA5,
KW ECO:0007829|MaxQB:A0A0G2JRA5};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW RNA-binding {ECO:0000256|PIRSR:PIRSR037932-1, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 120..196
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..47
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 121
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 129
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 130
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 154
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 159
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 163
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 187
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 197
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000486570.1"
SQ SEQUENCE 389 AA; 41243 MW; 16674A3F2E373579 CRC64;
NEPLTPGYHG FPARDSQGNQ EPTTTPDAMV QPFTTIPFPP PPQNGIPTEY GVPHTQDYAG
QTGEHNLTLY GSTQAHGEQS SNSPSTQNGS LTQTEGGAQT DGQQSQTQSS ENSESKSTPK
RLHVSNIPFR FRDPDLRQMF GQFGKILDVE IIFNERGSKG FGFVTFENSA DADRAREKLH
GTVVEGRKIE VNNATARVMT NKKMVTPYAN GWKLSPVVGA VYGPELYAAS SFQADVSLGN
DAAVPLSGRG GINTYIPLIS LPLVPGFPYP TAATTAAAFR GAHLRGRGRT VYGAVRAVPP
TAIPAYPGVV YQDGFYGADL YGGYAAYRYA QPATATAATA AAAAAAAYSD GYGRVYTADP
YHALAPAASY GVGAVASLYR GGYSRFAPY
//
