ID A0A0G2JUN6_RAT Unreviewed; 1886 AA.
AC A0A0G2JUN6;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Fer-1-like family member 6 {ECO:0000313|Ensembl:ENSRNOP00000069165.2};
GN Name=Fer1l6 {ECO:0000313|Ensembl:ENSRNOP00000069165.2,
GN ECO:0000313|RGD:1564703};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000069165.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000069165.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000069165.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000069165.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000069165.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR jPOST; A0A0G2JUN6; -.
DR Ensembl; ENSRNOT00000091077.2; ENSRNOP00000069165.2; ENSRNOG00000025300.7.
DR AGR; RGD:1564703; -.
DR RGD; 1564703; Fer1l6.
DR VEuPathDB; HostDB:ENSRNOG00000025300; -.
DR GeneTree; ENSGT00940000159069; -.
DR OMA; SPNEDMM; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000025300; Expressed in stomach and 5 other cell types or tissues.
DR ExpressionAtlas; A0A0G2JUN6; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007009; P:plasma membrane organization; IBA:GO_Central.
DR GO; GO:0009617; P:response to bacterium; ISO:RGD.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF37; FER-1-LIKE 6 (C. ELEGANS); 1.
DR Pfam; PF00168; C2; 6.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 6.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 6.
DR PROSITE; PS50004; C2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1852..1871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 87..206
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 244..378
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 835..962
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 994..1123
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1366..1485
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1604..1757
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 450..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1126..1150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1185..1228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1251..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1886 AA; 212449 MW; C6C4DC72436F206E CRC64;
MEKPSKAKYR SHGSFHPEET RKGMFGLKLK KKKKDKTEKG LVLTNKGAQD GSESEVPQEG
PSHQEGPEDL TYDDASITPG PSAPSKRRAK LLTKIHDGEV KSQNYQITIT ITEARQLVGE
NIDPVVTIEI GDEKKQSTVK EGTNSPFYNE YFVFDFIGPQ VHLFDKIIKI SVLHHKLIGS
ILIGSFRVDV GTVYNQPGHQ FCDKWALLTD PGDIRTGTKG YLKCDISVTG KGDILKTNPK
TSDAEEQIEK NLLIPQGFPS ERPWARFYVR LYRAEGLPKM NSSIMANVTK AFVGDSKDLV
DPFVEVSFAG QTGRTSVQKN CADPVWHEQV VFKEMFPPLC RRVKIQLWDE GSMNDVTLAT
HFIDLKKISN EQDGDKGFLP TFGPAWINLY GSPRNHSLMD DYQELNEGFG EGVSFRGRIL
VEIAVEILSG GAQESKFSKA LKELKLSSKD KDSKSSKGSS KDKADKADDG KAQQATDKTN
STEVEVESFA VPPEIIPEKY EDFLLFGAFF EATMIDRKIG DKPISFEVSV GNFGNLIDGG
SHHGSKKKSA ELMEEDVLPL LHEGEKDVAH DTAISMASTT HPEKPLVTDG NRNYNYLPFG
AKKPCVSFIS SWGDQIFRLH WSNMLEKMAD LLEEGIEEVR ELVKVSEEAP EEKMKTVLHD
FISQSRAFIS EAEKKQKTPN QTALDKKRLT LCWQELKAMT DEAEGVIQQQ KKKLSLDEMI
REAQNFVEKI RFLVDEPQHT IPDVFIWMLS NNKRVAYARI AAKDLLYSPI EEQMGKHCGK
IKTHFLKLPG KRPAGWTVQA KVDIYLWLGS TRYSDAVLDN LPAGYEAEMP SKSSGTHHPP
SALLYQAQHV FQLRAHMYQA RGLIAADSNG LSDPFAKVTF LSQCQTTKVI SQTLSPTWNQ
MLLFNELVLH GEERELMESP PLVVVELYDS DAVGKPEYLG ATVAAPVVTL ADQDYEPPKL
CYHPIFCGNL SGGDLLAVFE LLQVPSSGLQ GLPPTGPPDI TQIYPVPSNI RPVLSKYRVE
VLFWGVREMK KVQLLSVDRP QVLIECGGRG VKSCVIQSYK NNPNFSVQAE AFEVELPENE
LLHPPLSICV VDWRAFGRST LVGTYTINCL KQFLCKSREP LALTSQTDGA GARPAISDSP
AAVQSSELLS SSKDLPTDHV YVDIEPPPTE VPDSAQAQTA TLVDMPDSSP MLEPEHKPVA
QGLPKDGHIK QDPRMPSRRS TKRRRRTIAD ESAENVIDWW SKYYASVKKA QKEKENNHKE
KRDPKAKPGE VVLDVDDGPK KKKDKMFKKK LKDDGNEAIP NLAVLKIYDG DLESEFNNFE
DWVKTFELFR GKSTEDDHSL DGDRVIGKFK GSFCIYKSPE DSASEDSGQL RIQQGIPPNH
PIQVLIRVYI VAAFNLSPAD PDGKSDPYIV LRLGQTEIKD RDKYIPKQLN PVFGRSFEIQ
ATFPKESLLS VLIYDHDMIG SDDLIGETKI DLENRFYSKH RAICGLQSQY EIEGYNAWRD
TAKPTEILTK LCKDNMLDGP HFRPGKIQIG KKVFSGKTVF TEADSEEMVE SYEHLALKVL
HSWEDIPEVG CRLVPEHIET RPLYHKDKPG MEQGRLQMWV DIFPKDTPQL GPPVDISPRK
PKGYELRVTI WNTEDVILED ENIFTGQKSS DIYVKGWIKG LEDDRQETDV HYNSLTGEGN
FNWRFLFPFQ YLPAEKQMVI SKRENIFSLE KMECKTPAVL VLQVWDFERL SSDDFLGSLE
MNLNSFPRAA KSAKACDLSK FENASEENKI SIFQQKRVRG WWPFAKSKEL TGKVEAEFHL
VTAEEAEKNP VGKARKEPEP LAKPNRPDTS FSWFVSPFKC LYHLIWKNYK KYIIIAFILI
ILIVFLVLFI YTLPGAISRR IVVGGS
//
