ID A0A0G2JVD6_RAT Unreviewed; 5544 AA.
AC A0A0G2JVD6;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=[histone H3]-lysine(4) N-methyltransferase {ECO:0000256|ARBA:ARBA00023620};
DE EC=2.1.1.364 {ECO:0000256|ARBA:ARBA00023620};
GN Name=Kmt2d {ECO:0000313|Ensembl:ENSRNOP00000069442.2,
GN ECO:0000313|RGD:2324324};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000069442.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000069442.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000069442.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000069442.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000069442.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = H(+) +
CC N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:60264, Rhea:RHEA-COMP:15543, Rhea:RHEA-COMP:15547,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.364;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60265;
CC Evidence={ECO:0000256|ARBA:ARBA00024515};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_017450810.1; XM_017595321.1.
DR jPOST; A0A0G2JVD6; -.
DR PaxDb; 10116-ENSRNOP00000044890; -.
DR Ensembl; ENSRNOT00000077502.2; ENSRNOP00000069442.2; ENSRNOG00000061499.2.
DR GeneID; 100362634; -.
DR AGR; RGD:2324324; -.
DR CTD; 8085; -.
DR RGD; 2324324; Kmt2d.
DR VEuPathDB; HostDB:ENSRNOG00000061499; -.
DR eggNOG; KOG4443; Eukaryota.
DR GeneTree; ENSGT00940000156707; -.
DR OMA; EFHYVDT; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000061499; Expressed in heart and 20 other cell types or tissues.
DR ExpressionAtlas; A0A0G2JVD6; baseline and differential.
DR GO; GO:0044666; C:MLL3/4 complex; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0042800; F:histone H3K4 methyltransferase activity; ISO:RGD.
DR GO; GO:0140999; F:histone H3K4 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISO:RGD.
DR GO; GO:0031507; P:heterochromatin formation; ISO:RGD.
DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0001555; P:oocyte growth; ISO:RGD.
DR GO; GO:0048477; P:oogenesis; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
DR GO; GO:0043627; P:response to estrogen; ISO:RGD.
DR CDD; cd15695; ePHD1_KMT2D; 1.
DR CDD; cd15698; ePHD2_KMT2D; 1.
DR CDD; cd22027; HMG-box_KMT2D; 1.
DR CDD; cd15509; PHD1_KMT2C_like; 1.
DR CDD; cd15597; PHD3_KMT2D; 1.
DR CDD; cd15513; PHD5_KMT2C_like; 1.
DR CDD; cd15601; PHD5_KMT2D; 1.
DR CDD; cd19209; SET_KMT2D; 1.
DR Gene3D; 3.30.160.360; -; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 6.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR003889; FYrich_C.
DR InterPro; IPR003888; FYrich_N.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR041961; KMT2D_ePHD1.
DR InterPro; IPR041964; KMT2D_ePHD2.
DR InterPro; IPR047000; KMT2D_PHD3.
DR InterPro; IPR046999; KMT2D_PHD5.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR037890; SET_KMT2D.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45888:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE 2D; 1.
DR PANTHER; PTHR45888; HL01030P-RELATED; 1.
DR Pfam; PF05965; FYRC; 1.
DR Pfam; PF05964; FYRN; 1.
DR Pfam; PF00628; PHD; 4.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00542; FYRC; 1.
DR SMART; SM00541; FYRN; 1.
DR SMART; SM00398; HMG; 1.
DR SMART; SM00249; PHD; 7.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00184; RING; 6.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 5.
DR SUPFAM; SSF47095; HMG-box; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51805; EPHD; 2.
DR PROSITE; PS51543; FYRC; 1.
DR PROSITE; PS51542; FYRN; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS50016; ZF_PHD_2; 5.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0G2JVD6};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 104..218
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 226..276
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 229..274
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 273..323
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1334..1387
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1384..1434
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 1461..1516
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 5036..5144
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 5404..5520
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 5528..5544
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..1289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1297..1316
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1567..1722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1751..1846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1890..1959
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2126..2472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2508..2642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2659..2747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2813..2972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3064..3183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3239..3283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3442..3475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3572..3693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3748..3768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3805..3824
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3998..4018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4051..4205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4246..4400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4433..4456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4497..4552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4620..4737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4833..4864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4912..4987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3703..3735
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3904..3995
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..618
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..691
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..899
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..1008
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1159..1175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1590..1618
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1629..1646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1701..1722
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1765..1796
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1931..1959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2145..2165
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2166..2185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2313..2364
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2367..2387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2400..2435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2528..2555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2607..2636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2689..2709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3243..3265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3442..3463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3572..3604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3644..3685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3998..4014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4088..4143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4155..4190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4246..4269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4316..4334
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4344..4360
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4500..4517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4521..4552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4627..4641
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4654..4677
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4834..4848
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4916..4963
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4969..4987
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5544 AA; 595654 MW; 3DB67F3008E58EB8 CRC64;
MDSQKPPAED KDSDPAADGL AAPEKPGATE PHLPILCIGE VSVPSSGSSR LQKPPHDCSG
GPARRCALCN CGEPSLHGQR ELQRFELPSD WPGFPVVSSG GSSGPCEAVL PNEDLSQIGF
PEGLTPAHLG EPGGHCWAHH WCAAWSAGVW GQEGPELCGV DKAVFSGISQ RCSHCARFGA
SVPCRSPGCS RLYHFPCATA SGSFLSMRTL QLLCPEHSDG AAHLEEAHCA VCEGPGELCD
LFFCTSCGHH YHGACLDTAL TARKRAGWQC PECKVCQACR KPGNDSKMLV CETCDKGYHT
FCLKPPIEDL PAHSWKCKTC RICRACGAGS ADLNPNSEWF ENYSLCHRCH KVQGSQPVIS
VAEQHPAVCS RFSPPEPGET PTEEPSALYV TCQGQPKGTH VTSVQPKEPG PLQCEAKPLG
REGTQLEAQL EAPLNEEMPL LPPPEESPLS PPPEESPTSP PPEASRLSPP TEESPLSPPP
ESSPFSPLEE SPPSPALDTP LSPPPEASPL SPPFEESPLS PPPEELPSSP PPEASRLSPP
PEESPMSPPP EESPMSPPPE ASRLFPPFEE SPLSPPPEDS PLSPPPEASR LSPPPEDSPM
SPPPEDSPMS PPPEVSRFSP LPVLSHLSPL PEVSRLSPPP EESPLSPPPE DSPTSPPPEA
SRLSPPPEDS PASPPPEASQ LSPPHEESPA SPPPEDSLMS LPMEESPLSP LPEELRLCPQ
PEEPYLSPQP EEPRLCLQPE ELPLSPQSEE PCLSPVLAEP CLSSQPEELR LSPVPQEPHL
SPQPKQLHLS PQSEEPCLSP MPEEPCLYSQ PEELHRSPQP QEPPEEPSQC PAPKELSLFP
PSREPPLSPM LREPALSEPG EPPLSPLPEE LPLSLSGEPV LSPQLMPPDP LPPPLSPIIP
AAAPPALSPL GELEYPFGAK GDSDPESPLA APILETPISP PPEANCTDPE PVPPMILPPS
PGSPMGPASP ILMGPLPPPC SPLLQHSLPP PTPPPSHCSP PALPLSVPSP LSPVQKEVGV
SGEAGLHEME TEKGPEPECP ALEPRATSPL PSPMGDLSCP APSPAPALDD FSGLGEDTTP
LDGTDADPLQ SQTGQNSGSL ASELKGSPVL LDPEELIPVT PMEVYGPECK QAEQGSPCEE
QEEPGAPMAP MPPTLIKSDI VNEISNLSQG DASASFPGSE PLLGSPDPEG AGSLSMELGV
STDVSPARDE GSLRLCTDSL PETDDSLLCD TGTATSGGKA EGDKGRRRSS PARSRIKQGR
SSSFPGRRRP RGGAAHGGRG RGRARLKSTT SSIETLVVAD IDSSPSKEEE EEDDDTMQNT
VVLFSNTDKF VLMQDMCVVC GSFGRGAEGH LLACSQCSQC YHPYCVNSKI TKVMLLKGWR
CVECIVCEVC GQASDPSRLL LCDDCDISYH TYCLDPPLLT VPKGGWKCKW CVSCMQCGAA
SPGFHCEWQN SYTHCGPCAS LVTCPICHAP YVEEDLLIQC RHCERWMHAG CESLFTEDEV
EQAADEGFDC VSCQPYVVKP VVPVAPPELV PVKVKEPEPQ FFRFEGVWLT ETGMAVLRNL
TMSPLHKRRQ RRGRLGLPGE AGLEGSEPSD ALGPDDKKDG DLDTEELLKG EGGVEQMECE
IKLEGPASPD VELGKEETEE SKKRKRKPYR PGIGGFMIRQ RKSHTRVKRG PAAQAEGSSG
DGQPDEVMPA DLPAEGSVEQ SLAEGDEKKK QQRRGRRKSK LEDMFPAYLQ EAFFGKELLD
LSRKALFAVG VGRPGFGLGT SKPRGDGGSD RKELVTALHK GDDGPDVADE ESHGPEGTAD
VAGLEDGAVK ASPVPSDPEK PGTPGEGVLS SDLDRIPTEE LPKMESKDLQ QLFKDVLGSE
REQHLGCGTP GLEGSRTPLQ RPFLQGGLAL GSLPSSSPMD SYPGLCQSPF LDSRERGGFF
SPEPGEPDSP WTGSGGTTPS TPTTPTTEGE GDGLSYNQRS LQRWEKDEEL GQLSTISPVL
YANINFPNLK QDYPDWSSRC KQIMKLWRKV PAADKAPYLQ KAKDNRAAHR INKVQKQAES
QISKQAKMGD VARKTERPAL HLRIPSQPGA LGSPPPAAAP TIFLGSPTTP AGLSTSADGF
LKPPAGTVPG PDSPGELFLK LPPQVPAQVP SQDPFGLAPA YAPEPRFSAA PPTYPPYPSP
TGAPVQPPML GTTTRPGTGQ PGEFHTTPPG TPRHQPSTPD PFLKPRCPSL DNLAVPESPG
VAGGKASEPL LSPPPFGESR KSLEVKKEDL GASSPGYGPP NLGCVDSPSS GPHLGGLELK
APDVFKAPLT PRASQVEPQS PGLGLRAQEP PPAQALAPSP PNHPDIFRSG PYPDPYAQPP
LTPRPQPPPP ESCCAPPPRS LPSDPFSRVP ASPQSQSSSQ SPLTPRPLST EAFCPSPVTP
RFQSPDPYSR PPSRPQSRDP FAPLHKPPRP QPPEVAFKAG PLAHTPLGAG GFPAALPSGP
AGELHAKVPS GQPTHFARSP GTGTFAGTPS PMRFTFPQGV GEPSLKPPVP QPGLPSPHGI
NSHFGPGPTL GKPQSTNYAV ATGNFHPSGS PLGPNSGPTG EGYGLSPLRP ASVLPPPTPD
GSLPYLSHGA SQRVGITSPV EKREDPGATM SSSSVATPEL SSAQDTGMSS LSQTELEKQR
QRQRLRELLI RQQIQRNTLR QEKETAAAAA GAVGPPGNWG AEPSGPAFDQ LSRAQTPFTG
SQDRNSVVGL PSSKLGGPIL GPGAFSSDDR LSRPLPPATP SSMDMNSRQL VGGSQAFYQR
TPYPGSLPLQ QQQQQQQQQQ QQQQQQQQQQ QLWQQQQAAA AAATSMRLAM SARFPSTPGP
ELGRQALGSP LAGIPTRLPG PAEPVPGPAG PAQFIELRHN VQKGLGPGVS PFPGQGPPQR
PRFYPISEEP HRLAPEGLRG LAVSGLPPQK PSAPPAPELN NSLHQPPHTK GPTLPAGLEL
VSRPPSTTDL GRPPLALEAG KLPCEDPELD DDFDAHKALE DDEELAHLGL GVDVAKGDDE
LGTLEHLETN DPHLDDLLNG DEFDLLAYTD PELDTGDKKD IFNEHLRLVE SANEKAEREA
LLRGVEPISL GPEEQRPPPA PDNSEPRLTS VLPEVKPKVE EGGRHPSPCQ FTINTPKVEP
APPATPLSLG LKPGQTVMGS RDTRVGVGTG PFPSSGHTAE KGPFGATGGT PAHLLNPSSL
SGSAGSSLLE KFELESGTLT LPSGNVAPGD ELDKMESSLV ASELPLLIED LLEHEKKELQ
KRQQLSAQTV LPAQPQQQQQ QHQHPLLPVP GPAQALPLPH ESGPPQQLAL GLGSTRQPGL
GQSMMAAQSP AHALQQRLAP SVAMVSNQGH MLSGQQAGQT GLVPQQSSQP VLAQKPMNAM
PASMCMKPQQ LAMQQQQLAN SFFPDTDLDK FAAEDIIDPI AKAKMVALKG IKKVMAQGSI
GVAPGMNRQQ VSLLAQRLSG ASGSDLQNHA AAGSGQERNA SDPSQPRPNP PTFAQGVINE
ADQRQYEEWL FHTQQLLQMQ LKVLEEQIGV HRKSRKALCA KQRTAKKAGR EFPEADAEKL
KLVTEQQSKI QKQLDQVRKQ QKEHTNLMAE YRNKQQQQQQ QQQQQQQHSA VLAVSPSQNP
RVLTKHPGQL LPGHGLQPPQ VPPGGQAGGL RLPPGGMVLP GQSGGPFLNT TLAQQQQQQQ
QQQQQQQQQQ QHSGVAGSLT GPSGSFFPGN LALRSLGPDS RLLQERQLQL QQQRMQLAQK
LQQQQQQQQQ QQQQQLLGQV AVQQQQGPVG QNQALGPKPQ GLLPPSNHQG LLVQQLSPQQ
SQGSQGMLGS SQVAVLQQQQ QQQQQQQQQQ QQQHSGALGP QGPHRQVLMT QSRVLSSPQL
AQQGHGLMGH RLLTAQQQQQ QQQQQQQQQQ QQQQGSMTGL SQLQQGMMSH GGQPKMSVQA
LGSLQQQQQQ QQQLQQQQQQ MQQLQQQQQQ QLQQQQQQQM QQLQQQQQQL QQQQQQQQQQ
QQLHLQQQLH QQQQLQQQQL QLQQQQQQMS LLNQNRTLLS PQQQQQQQQQ VTLGPGMPVK
PLQHFSSPGA LGPALLLTGK EQNIAETALP SEVTEGPSAH QGGPPTVGTT PESMSVEPGE
VKPSISGDSQ LLLVQSQPTS VQLQPPLRLP GQPQQVNLLH TTGGGSHGQQ LGSGSSSEAP
SGPHLLAQPS VSLGEQPGPM AQNLLGSQQP LGLERPIQNN TGSQPPKSGP APQSGQGPPG
VGVMPTVGQL RAQLQGVLAK TPQLRHLSPQ QQQQLQALLM QRQLQQSQAV RQMPPGQESG
TQPSPLQGLL GCQPQPGVFS ASQIGPLQEL GAGSRPQGPP RLPVPQGALS TGPVLGPVHP
TPPPSSPQEP KRPSQLPSPS AQLTPTHPGT PKPQGPASEL PPGRVSPAAA QLADAFFGKG
LGPWDPSDNL PEAQKPEQSS LAAGRLEQVN GQVAHEPSHL SIKQEPREEP CALGAQTVKR
EANGEPAGAP GTSNHLLLAG SRSEAGHLLL QKLLRAKNVQ LGAGRGPEGL RAEINGHVDS
KLSGQEQKLQ GTSSSKEDAA ARKPLMAKPK RVQKTSDRLA SSRKKLRKED GVRANEALLK
QLKQELSQLP LTEPTITANF SLFAPFGSGC LVGGQSQLRG AFGSGALHTG PDYYSQLLTK
NNLSNPPTPP SSLPPTPPPS VQQKMVNGVT PSEELGEHPK DAASAQDSER TLKDAAEVKS
LDLLAALPTP PHNQTEDVRM ESDEDSDSPD SIVPASSPES ILGEEAPRFP QLGSGRWEQD
TRALSPVIPI IPRTSIPVFP DTKPYGVLDL EVPGKPPATA WEKGKGSEVS VMLTVSAAAA
KNLNGVMVAV AELLSMKIPN SYEVLFPDGP ARAGLEPKKG ETEGSGGKEK GLSGRGPDTG
PDWLKQFDAV LPGYTLKSQL DILSLLKQES PAPEPSIQHS YTYNVSNLDV RQLSAPPPEE
PSPPPSPLAP SPASPPAEPM VELQAEPPAE PPIPSPLPLA SSPEATRPKP RARPPDESED
SRPPRLKKWK GVRWKRLRLL LTIQKGSGRQ EDEREVAEFM EQLGTALRPS KVPRDNRRCC
FCHEEGDGAT DGPARLLNLD LDLWVHLNCA LWSTEVYETQ GGALMNVEVA LHRGLLTKCS
LCQRTGATGS CNRMRCPNVY HFACAIRAKC MFFKDKTMLC PMHKIKGPCE QELSSFAVFR
RVYIERDEVK QIASIIQRGE RLHMFRVGGL VFHAIGQLLP HQMADFHSAT ALYPVGYEAT
RIYWSLRTNN RRCCYRCSIS ENNGRPEFVI KVIEQGLEDL VFTDASPQAV WNRIIEPVAA
MRKEADMLRL FPEYLKGEEL FGLTVHAVLR IAESLPGVES CQNYLFRYGR HPLMELPLMI
NPTGCARSEP KILTHYKRPH TLNSTSMSKA YQSTFTGETN TPYSKQFVHS KSSQYRRLRT
EWKNNVYLAR SRIQGLGLYA AKDLEKHTMV IEYIGTIIRN EVANRREKIY EEQNRGIYMF
RINNEHVIDA TLTGGPARYI NHSCAPNCVA EVVTFDKEDK IIIISSRRIP KGEELTYDYQ
FDFEDDQHKI PCHCGAWNCR KWMN
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