GenomeNet

Database: UniProt
Entry: A0A0G2JX93_RAT
LinkDB: A0A0G2JX93_RAT
Original site: A0A0G2JX93_RAT 
ID   A0A0G2JX93_RAT          Unreviewed;      1083 AA.
AC   A0A0G2JX93;
DT   22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT   22-JUL-2015, sequence version 1.
DT   05-JUN-2019, entry version 34.
DE   RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN   Name=Stat1 {ECO:0000313|RGD:3771};
GN   Synonyms=Stat4 {ECO:0000313|Ensembl:ENSRNOP00000070183,
GN   ECO:0000313|RGD:1305747};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000070183, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000070183, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000070183,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
RA   Lundby C., Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14
RT   different rat organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
RN   [3] {ECO:0000313|Ensembl:ENSRNOP00000070183}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000070183};
RG   Ensembl;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU046415}.
CC       Nucleus {ECO:0000256|RuleBase:RU046415}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000256|RuleBase:RU046415}.
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DR   EMBL; AABR07067607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07067608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07067609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07067610; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07067611; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07067612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07073481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC094675; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   SMR; A0A0G2JX93; -.
DR   jPOST; A0A0G2JX93; -.
DR   Ensembl; ENSRNOT00000080522; ENSRNOP00000070183; ENSRNOG00000014079.
DR   RGD; 3771; Stat1.
DR   RGD; 1305747; Stat4.
DR   GeneTree; ENSGT00950000182688; -.
DR   Reactome; R-RNO-1059683; Interleukin-6 signaling.
DR   Reactome; R-RNO-1169408; ISG15 antiviral mechanism.
DR   Reactome; R-RNO-1433557; Signaling by SCF-KIT.
DR   Reactome; R-RNO-186763; Downstream signal transduction.
DR   Reactome; R-RNO-6785807; Interleukin-4 and Interleukin-13 signaling.
DR   Reactome; R-RNO-877300; Interferon gamma signaling.
DR   Reactome; R-RNO-877312; Regulation of IFNG signaling.
DR   Reactome; R-RNO-8854691; Interleukin-20 family signaling.
DR   Reactome; R-RNO-8984722; Interleukin-35 Signalling.
DR   Reactome; R-RNO-8985947; Interleukin-9 signaling.
DR   Reactome; R-RNO-9020956; Interleukin-27 signaling.
DR   Reactome; R-RNO-9020958; Interleukin-21 signaling.
DR   Reactome; R-RNO-909733; Interferon alpha/beta signaling.
DR   Reactome; R-RNO-912694; Regulation of IFNA signaling.
DR   Proteomes; UP000002494; Chromosome 9.
DR   Bgee; ENSRNOG00000014079; Expressed in 9 organ(s), highest expression level in testis.
DR   ExpressionAtlas; A0A0G2JX93; baseline and differential.
DR   GO; GO:0030424; C:axon; IDA:RGD.
DR   GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0030425; C:dendrite; IDA:RGD.
DR   GO; GO:0005634; C:nucleus; IDA:RGD.
DR   GO; GO:0031730; F:CCR5 chemokine receptor binding; IPI:RGD.
DR   GO; GO:0003677; F:DNA binding; IDA:RGD.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:RGD.
DR   GO; GO:0051721; F:protein phosphatase 2A binding; IPI:RGD.
DR   GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:RGD.
DR   GO; GO:0008015; P:blood circulation; IMP:RGD.
DR   GO; GO:0071345; P:cellular response to cytokine stimulus; IDA:MGI.
DR   GO; GO:0032869; P:cellular response to insulin stimulus; IDA:RGD.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IDA:MGI.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006952; P:defense response; IBA:GO_Central.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:RGD.
DR   GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IMP:RGD.
DR   GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IMP:RGD.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0051591; P:response to cAMP; IDA:RGD.
DR   GO; GO:0034097; P:response to cytokine; IDA:RGD.
DR   GO; GO:0042493; P:response to drug; IDA:RGD.
DR   GO; GO:0042542; P:response to hydrogen peroxide; IEP:RGD.
DR   GO; GO:0009612; P:response to mechanical stimulus; IDA:RGD.
DR   GO; GO:0007584; P:response to nutrient; IDA:RGD.
DR   GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR   GO; GO:0043434; P:response to peptide hormone; IDA:RGD.
DR   GO; GO:0060337; P:type I interferon signaling pathway; IBA:GO_Central.
DR   CDD; cd10372; SH2_STAT1; 1.
DR   Gene3D; 1.10.532.10; -; 1.
DR   Gene3D; 1.10.8.1200; -; 1.
DR   Gene3D; 2.60.40.630; -; 1.
DR   Gene3D; 3.30.505.10; -; 2.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR038295; STAT1_C_sf.
DR   InterPro; IPR035859; STAT1_SH2.
DR   InterPro; IPR022752; STAT1_TAZ2-bd_C.
DR   InterPro; IPR036535; STAT_N_sf.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   InterPro; IPR013799; STAT_TF_prot_interaction.
DR   PANTHER; PTHR11801; PTHR11801; 3.
DR   Pfam; PF00017; SH2; 2.
DR   Pfam; PF12162; STAT1_TAZ2bind; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 2.
DR   Pfam; PF02865; STAT_int; 1.
DR   SMART; SM00964; STAT_int; 1.
DR   SUPFAM; SSF47655; SSF47655; 1.
DR   SUPFAM; SSF48092; SSF48092; 1.
DR   SUPFAM; SSF49417; SSF49417; 2.
DR   SUPFAM; SSF55550; SSF55550; 2.
DR   PROSITE; PS50001; SH2; 2.
PE   1: Evidence at protein level;
KW   Activator {ECO:0000256|RuleBase:RU046415};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Cytoplasm {ECO:0000256|RuleBase:RU046415};
KW   DNA-binding {ECO:0000256|RuleBase:RU046415};
KW   Nucleus {ECO:0000256|RuleBase:RU046415};
KW   Phosphoprotein {ECO:0000256|RuleBase:RU046415};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0G2JX93};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191,
KW   ECO:0000256|RuleBase:RU046415};
KW   Transcription {ECO:0000256|RuleBase:RU046415};
KW   Transcription regulation {ECO:0000256|RuleBase:RU046415}.
FT   DOMAIN      152    247       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   DOMAIN      907   1004       SH2. {ECO:0000259|PROSITE:PS50001}.
FT   COILED      526    546       {ECO:0000256|SAM:Coils}.
FT   COILED      646    670       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1083 AA;  125241 MW;  BC0D7796BFDC3607 CRC64;
     GCHMVTEELH SITFETQICL YGLTINLETS SLPVVMISNV SQLPNAWASI IWYNVSTNDS
     QNLVFFNNPP SVTLGQLLEV MSWQFSSYVG RGLNSDQLNM LAEKLTVQSN YSDGHLTWAK
     FCKEHLPGKT FTFWTWLEAI LDLIKKHILP LWIDGYIMGF VSKEKERLLL KDKMPGTFLL
     RFSESHLGGI TFTWVDQSEN GEVRFHSVEP YNKARLSALP FADILRDYKV IMAENIPENP
     LKYLYPDIPK DKAFGKHYSS QPCEVPRKHV VRLFPAAASL PPQFANRVAA APPVANLWFL
     WKSEEGTRYP GTGVGNRHDG TANPTPVLCK GKFFLTAELR PIISTLFHPL SRRHSVHQAY
     NLLCWSLVLN PQSAPGDSPR MSQWYELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK
     QDWEHAAYDV SFATIRFHDL LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPVQ
     MSMIIHNCLK EERKILENAQ RFNQAQEGNI QNTVMLDKQK ELDSKVRNVK DQVMCIEHEI
     KTLEDLQDEY DFKCKTSQNR ESEANGVAKS DQKQEQLLLH KMFLMLDNKR KEIIHKIREL
     LNSIELTQNT LINDELVEWK RRQQSACIGG PPNACLDQLQ SWFTIVAESL QQVRQQLKKL
     EELEQKFTYE QDPITKNKQV LSDRTFVLFQ QLIQRLLVKL QELNYNLKVK VSFDKDVNEK
     NTVKGSKHFK DLCLALYRFR KFNILGTHTK VMNMEESTNG SLAAEFRHLQ LKEQKNAGNR
     TNETTSLPVV VISNVSQLPS GWASILWYNM LVTEPRNLSF FLNPPCAWWS QLSEVLSWQF
     SSVTKRGLNA DQLSMLGEKL LGPNAGPDGL IPWTRFCKEN INDKNFSFWP WIDTILELIK
     KHLLCLWNDG CIMGFISKER ERALLKDQQP GTFLLRFSES SREGAITFTW VERSQNGGEP
     DFHAVEPYTK KELSAVTFPD IIRNYKVMAA ENIPENPLKY LYPNIDKDHA FGKYYSRPKE
     APEPMELDDP KRTGYIKTEL ISVSEVHPSR LQSTENLLPM SPEEFDEMSK IVGSEFDSMV
     SSV
//
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