ID A0A0G2JZE8_RAT Unreviewed; 504 AA.
AC A0A0G2JZE8;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2015, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Target of EGR1, exonuclease {ECO:0000313|Ensembl:ENSRNOP00000071019.1};
GN Name=Toe1 {ECO:0000313|Ensembl:ENSRNOP00000071019.1,
GN ECO:0000313|RGD:1309094};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000071019.1, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000071019.1, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071019.1,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [3] {ECO:0000313|Ensembl:ENSRNOP00000071019.1}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000071019.1};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CAF1 family.
CC {ECO:0000256|ARBA:ARBA00008372}.
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DR RefSeq; XP_006238713.1; XM_006238651.2.
DR AlphaFoldDB; A0A0G2JZE8; -.
DR SMR; A0A0G2JZE8; -.
DR IntAct; A0A0G2JZE8; 6.
DR STRING; 10116.ENSRNOP00000071019; -.
DR Ensembl; ENSRNOT00000087237.2; ENSRNOP00000071019.1; ENSRNOG00000017561.6.
DR AGR; RGD:1309094; -.
DR CTD; 114034; -.
DR RGD; 1309094; Toe1.
DR GeneTree; ENSGT00940000153167; -.
DR OMA; EQGHKND; -.
DR OrthoDB; 2879493at2759; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000017561; Expressed in thymus and 19 other cell types or tissues.
DR ExpressionAtlas; A0A0G2JZE8; baseline and differential.
DR GO; GO:0015030; C:Cajal body; ISO:RGD.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; ISO:RGD.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; ISO:RGD.
DR GO; GO:0017069; F:snRNA binding; ISO:RGD.
DR GO; GO:0034472; P:snRNA 3'-end processing; ISO:RGD.
DR Gene3D; 6.10.250.3220; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006941; RNase_CAF1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR15092; POLY A -SPECIFIC RIBONUCLEASE/TARGET OF EGR1, MEMBER 1; 1.
DR PANTHER; PTHR15092:SF37; TARGET OF EGR1 PROTEIN 1; 1.
DR Pfam; PF04857; CAF1; 2.
DR Pfam; PF00642; zf-CCCH; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 1: Evidence at protein level;
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
SQ SEQUENCE 504 AA; 56197 MW; 3595B98E31E57A36 CRC64;
MAADSDDGVP SVPTPSDGGV NRTTQSAEEF VVRVPVVDVQ SDNFKEIWPS LLLALKTASF
VAVDTELSGL GDRKSLLNQC IEERYKAVCH AARTRSVLSL GLACFKQQPD KGDSSYLAQV
FNLTLLCMEE YVIEPKSVQF LVQHGFNFNR QYAQGIPYHK GNDKGDESQS QSVRTLFLEL
IRARRPLVLH NGLIDLVFLY QNFYAHLPEN LGTFTADLCE MFPAGIYDTK YAAEFHARFV
ASYLEYAFRK CERENGKQRA AGSPHVALEF CSYPSSMRGH IDYRCCMSPV SCRHSHTTGI
CDKFSAYGWC PLGPQCPQSH DIDLIIDTDE AVAEDKRRRR RRKDKRKRAL QSQPETQTLE
EAEDGPPTKQ VCEDSLKTEK IEQKVAEGDQ LGSTQGHKDS LEMACKRTAD VPTSELLVNQ
ASPNPVPGDG LHRAGFDAFM TGYVMAYVGL SKGLQLCSSE PWLPECHNKV YLSGKTVPLT
VAKSQFSRPS KAHNQKMKLA WGSS
//