ID A0A0G2K6V6_RAT Unreviewed; 1272 AA.
AC A0A0G2K6V6;
DT 22-JUL-2015, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Kinesin family member 16B {ECO:0000313|Ensembl:ENSRNOP00000073957.2};
GN Name=Kif16b {ECO:0000313|Ensembl:ENSRNOP00000073957.2,
GN ECO:0000313|RGD:1310146};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000073957.2, ECO:0000313|Proteomes:UP000002494};
RN [1] {ECO:0000313|Ensembl:ENSRNOP00000073957.2, ECO:0000313|Proteomes:UP000002494}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073957.2,
RC ECO:0000313|Proteomes:UP000002494};
RX PubMed=15057822; DOI=10.1038/nature02426;
RG Rat Genome Sequencing Project Consortium;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2] {ECO:0000313|Ensembl:ENSRNOP00000073957.2}
RP IDENTIFICATION.
RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073957.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00283}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR jPOST; A0A0G2K6V6; -.
DR Ensembl; ENSRNOT00000083061.2; ENSRNOP00000073957.2; ENSRNOG00000004951.8.
DR AGR; RGD:1310146; -.
DR RGD; 1310146; Kif16b.
DR VEuPathDB; HostDB:ENSRNOG00000004951; -.
DR GeneTree; ENSGT00940000162977; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000004951; Expressed in adult mammalian kidney and 18 other cell types or tissues.
DR ExpressionAtlas; A0A0G2K6V6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; ISO:RGD.
DR GO; GO:0005768; C:endosome; ISO:RGD.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0045335; C:phagocytic vesicle; ISO:RGD.
DR GO; GO:0005819; C:spindle; ISO:RGD.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; ISO:RGD.
DR GO; GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; ISO:RGD.
DR GO; GO:0080025; F:phosphatidylinositol-3,5-bisphosphate binding; ISO:RGD.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISO:RGD.
DR GO; GO:0008574; F:plus-end-directed microtubule motor activity; ISO:RGD.
DR GO; GO:0031267; F:small GTPase binding; ISO:RGD.
DR GO; GO:0071346; P:cellular response to type II interferon; ISO:RGD.
DR GO; GO:0045022; P:early endosome to late endosome transport; ISO:RGD.
DR GO; GO:0007492; P:endoderm development; ISO:RGD.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; ISO:RGD.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; ISO:RGD.
DR GO; GO:0001704; P:formation of primary germ layer; ISO:RGD.
DR GO; GO:0006895; P:Golgi to endosome transport; ISO:RGD.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR GO; GO:0032801; P:receptor catabolic process; ISO:RGD.
DR GO; GO:0001919; P:regulation of receptor recycling; ISO:RGD.
DR CDD; cd06874; PX_KIF16B_SNX23; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF6; KINESIN-LIKE PROTEIN KIF1C ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF00787; PX; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002494}.
FT DOMAIN 1..319
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1137..1251
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 580..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 334..382
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 694..764
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 797..828
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 900..980
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1272 AA; 145946 MW; 06F293BD52F2157E CRC64;
MASVKVAVRV RPMNRREKDL EAKFIIQMEK SKTTITNLKI PEGGTGDSGR ERTKTFTYDF
SFYSADTKSP DYVSQETGDS GLIPRICEAL FSRINETTRW DEASFRTEVS YLEIYNERVR
DLLRRKSSKT FNLRVREHPK EGPYVEDLSK HLVQNYSDVE ELMDAGNINR TTAATGMNDV
SSRSHAIFTI KFTQAKFDAE MPCETVSKIH LVDLAGSERA DATGATGVRL KEGGNINKSL
VTLGNVISAL ADLSQDAANP LVKKKQVFVP YRDSVLTWLL KDSLGGNSKT IMIATISPAD
VNYGETLSTL RYANRAKNII NKPTINEDAN VKLIRELRAE IARLKTLLAQ GNQIALLDSP
TALSMEEKLH QNEARVQELT KEWTNKWNET QNILKEQTLA LRKEGIGVVL DSELPHLIGI
DDDLLSTGII LYHLKEGQTY VGREDASTEQ DIVLHGLDLE SEHCVFENAG GTVTLIPLSG
SQCSVNGVQI VDATQLNQGA VILLGRTNMF RFNHPKEAAK LREKRKSGLL SSFSLSMTDL
SKSCENLSAV MLYNPGLEFE RQQREELEKL ESKRKLIEEM EEKQKSDKAE LERMQQEVET
RRKETEIVQR QIRKQEESLK RRSFHIENKL KDLLAEKERF EEERLREQQG LEQQKRQEED
SFFRIREELR RLQELNSHEQ AEKGQPLQDL DWLHREQDAQ SAKLQLEKRR LEEQEKEQVL
RVAHLEEQLR KRQDTAPLLC PGEAQQAQEE RRELEGIRGA LLQAKEIRAG GDHTFRGELE
RAQQYFLEFK RRQLVKLATL EKDLVQQKDR LSKEVQEEKE ALEHVKCEAG EEPSLLATDN
CNILCGPQDL DKIKTAESRL QSKEHQLQDL LQNHLPALLE EKQRVLEILD CGVLGLDNIL
YHVEKEMEEK EEQITQYQAN ASQLQQLQAT VQFTANVARQ EEKVRRKEKE ILESQEKQQR
EALEQAVAKL EQRHSALKRR STLDLEIQEQ RQKLGSLHSS EWPGLQASLE ANGERLQMDP
ARIEHEIHEL KQKICEVDGV QRPHHGTLEG KAALSSLPPS AENSHLAPLM DARISAYIEE
EVQRRLHDLH RVISDASHAP AELKSNEELH NGATQRKLKY ERMYSRSLGA NPDDLKDPIK
ISIPRYVLCG QGKDEHFEFE VKISVLDETW TVFRRYSRFR EMHKTLKLKY AELAALEFPP
KKLFGNKDER VVAERRTHLE KYLREFFSVM LQSETSPLHI NKVGLTLSKH TICEFSPFFK
KGVFDYSSHG TG
//
