ID A0A0G3ASB1_9ACTN Unreviewed; 728 AA.
AC A0A0G3ASB1;
DT 16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT 16-SEP-2015, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:AKJ15297.1};
GN ORFNames=ABB07_36135 {ECO:0000313|EMBL:AKJ15297.1};
OS Streptomyces incarnatus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=665007 {ECO:0000313|EMBL:AKJ15297.1, ECO:0000313|Proteomes:UP000035366};
RN [1] {ECO:0000313|EMBL:AKJ15297.1, ECO:0000313|Proteomes:UP000035366}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL8089 {ECO:0000313|Proteomes:UP000035366};
RX PubMed=26159526;
RA Oshima K., Hattori M., Shimizu H., Fukuda K., Nemoto M., Inagaki K.,
RA Tamura T.;
RT "Draft Genome Sequence of Streptomyces incarnatus NRRL8089, which Produces
RT the Nucleoside Antibiotic Sinefungin.";
RL Genome Announc. 3:e00715-e00715(2015).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP011497; AKJ15297.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0G3ASB1; -.
DR STRING; 665007.ABB07_36135; -.
DR PATRIC; fig|665007.5.peg.7630; -.
DR Proteomes; UP000035366; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 178..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 549..570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 582..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 201..333
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 699..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 728 AA; 76538 MW; 16EA4E39ACF4F238 CRC64;
MFRRIGTTVV RHPVWTIVAW LIAAVAIVAT APSLPSNSDE SSFLPKSYES IKAADLQQRA
FPSAFTPSAI ALYQRTDGGR LTAADKQDIA RITTQLGDKH IDQVQKVVPG PPSKDGRYGL
TLVQMDSKNA GQPKQADAAK VLRDDVKQLA KGTHLDVKLG GSAAQALDQQ DSSKRGQALI
GFGTFAIILI TLLIIFRAPI LAVLPLVLIG LVSAVANGLI AYATKLFDLQ ANSSISSILI
VVLFGVGTDY FLFLMFRYRE RLRAGDEPKQ AMVNAVARVG EAIASAAGAV IIAFLALVLS
TLGFLKQMGP ALAIAVGATL VAGLTLIPAV VSLIGPKVFW PSKSWQNEPE NARFAALGRG
VRRRPALTAA LSGLVLVALS LGIFSFHATF DLASGSMPKT KESMVVQDQM QKAYSAGAAA
PTDVYLSSIG GKPLHKAAFG AYVSKLGAVD GVANARLTQV NKDGSTADIT VTLKYEASTD
KAIETVGKVR DVAHTNAPDG TKALVGGMSS IYKDINTAVN HDYKTVFPVA AVLIMVILGL
LLRSVVAPWY LMASVGLGFG ATLGATVWIF QKGEGHSGLM FMLPVIMYLF VVAIGTDYNI
LMIARLREEA REGREPREAA GMALRHAGPT VAAAGFILAA TFATMMLAGN SLLTEMGFAV
SFGIAVAAFV MALFFTPSLT ALIGHAAWWP GHGDRAEAAP AGVGTGGSVP APGTDRDSVA
HDSAGRRN
//
