ID   A0A0G3CSX9_9GAMM        Unreviewed;       473 AA.
AC   A0A0G3CSX9;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Cytosine-specific methyltransferase {ECO:0000256|RuleBase:RU000417};
DE            EC=2.1.1.37 {ECO:0000256|RuleBase:RU000417};
GN   ORFNames=QQ39_04970 {ECO:0000313|EMBL:AKJ43765.1};
OS   Pragia fontium.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Budviciaceae; Pragia.
OX   NCBI_TaxID=82985 {ECO:0000313|EMBL:AKJ43765.1, ECO:0000313|Proteomes:UP000068021};
RN   [1] {ECO:0000313|EMBL:AKJ43765.1, ECO:0000313|Proteomes:UP000068021}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=24613 {ECO:0000313|EMBL:AKJ43765.1,
RC   ECO:0000313|Proteomes:UP000068021};
RX   PubMed=26159528;
RA   Snopkova K., Sedlar K., Bosak J., Chaloupkova E., Provaznik I., Smajs D.;
RT   "Complete Genome Sequence of Pragia fontium 24613, an Environmental
RT   Bacterium from the Family Enterobacteriaceae.";
RL   Genome Announc. 3:e00740-15(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC         methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC         Evidence={ECO:0000256|ARBA:ARBA00000743,
CC         ECO:0000256|RuleBase:RU000417};
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
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DR   EMBL; CP010423; AKJ43765.1; -; Genomic_DNA.
DR   RefSeq; WP_047782524.1; NZ_UGTK01000001.1.
DR   AlphaFoldDB; A0A0G3CSX9; -.
DR   STRING; 82985.QQ39_04970; -.
DR   REBASE; 113526; M.Pfo24613ORF4970P.
DR   KEGG; pfq:QQ39_04970; -.
DR   PATRIC; fig|82985.3.peg.1049; -.
DR   OrthoDB; 9813719at2; -.
DR   Proteomes; UP000068021; Chromosome.
DR   GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   CDD; cd00315; Cyt_C5_DNA_methylase; 1.
DR   Gene3D; 1.10.260.140; -; 1.
DR   Gene3D; 3.90.120.30; -; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR018117; C5_DNA_meth_AS.
DR   InterPro; IPR001525; C5_MeTfrase.
DR   InterPro; IPR031303; C5_meth_CS.
DR   InterPro; IPR040743; DNA_meth_N.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; TIGR00675; dcm; 1.
DR   PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR   Pfam; PF18284; DNA_meth_N; 1.
DR   Pfam; PF00145; DNA_methylase; 1.
DR   PRINTS; PR00105; C5METTRFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00094; C5_MTASE_1; 1.
DR   PROSITE; PS00095; C5_MTASE_2; 1.
DR   PROSITE; PS51679; SAM_MT_C5; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000068021};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01016};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU01016}.
FT   DOMAIN          28..84
FT                   /note="DNA methylase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18284"
FT   ACT_SITE        186
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ   SEQUENCE   473 AA;  54368 MW;  34A2AE169207940F CRC64;
     MKEFDLVTQS IIEQALVKQQ QQLEDDKKLI QQLLEIFDQK AIAEVLRKIG VADWSRESLN
     RWINGKSIQK PLAEVESDVL RKMLPNPPKN HPDYKFRFID LFAGIGGIRK GFEDIGGQCV
     FTSEWNKDAV RTYKANWYCD SKEHKFNSDI REITLSEQND ISEVEAYEHI DKHIPDHDVL
     LAGFPCQPFS LAGVSKKNSL GKAHGFECET QGTLFFDVAR IIATKKPAIF LLENVKNLKS
     HDKGKTFRII MDTLDELGYD VSDADSTGSD DPKVIDGKSF IPQHRERIVL VGFRRDLDIY
     KDFTLKNISQ FFPEKRPTFE ELLESDVDKK YILTPALWKY LYNYAKKHQA KGNGFGFGLV
     NPQNKDSCAR TLSARYHKDG SEILIDRGWD KELGEIDFDD DKNQENRPRR LTPRECARLM
     GFERPGETLF RIPVSDTQAY RQFGNSVVVP VFSAVAKLLE PYIMQAVELN TER
//